Chronic hepatitis B virus in the Philippines

被引:10
作者
Gish, Robert G. [1 ,2 ,3 ,4 ,9 ]
Sollano, Jose D., Jr. [7 ]
Lapasaran, Alex [5 ,6 ]
Ong, Janus P. [8 ]
机构
[1] Stanford Univ, Dept Med, Div Gastroenterol & Hepatol, Stanford, CA 94305 USA
[2] Natl Viral Hepatitis Roundtable, San Francisco, CA USA
[3] FAIR Fdn, Palm Desert, CA USA
[4] Hepatitis B Fdn, Doylestown, PA USA
[5] Univ Nevada, Sch Nursing, Reno, NV 89557 USA
[6] Univ Nevada, Sch Med, Reno, NV 89557 USA
[7] Univ Santo Tomas, Gastroenterol Sect, Manila, Philippines
[8] Univ Philippines, Philippine Gen Hosp, Dept Med, Gastroenterol Sect, Manila, Philippines
[9] 6022 La Jolla Mesa Dr, San Diego, CA 92037 USA
关键词
chronic hepatitis B; epidemiology; HBsAg prevalence; hepatitis B; screening; surveillance; treatment; vaccination; NATURAL-HISTORY; HEPATOCELLULAR-CARCINOMA; VERTICAL TRANSMISSION; SURFACE-ANTIGEN; INFECTION; HEALTH; VACCINATION; DISEASE; AGE; IMMUNOPROPHYLAXIS;
D O I
10.1111/jgh.13258
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Multiple studies have shown a high prevalence of chronic hepatitis B (CHB) infection in the Philippines, not only in high-risk populations but also in the general population. The most recent national study estimated HBsAg seroprevalence to be 16.7%, corresponding to an estimated 7.3 million CHB adults. The factors underlying the high prevalence of CHB and its sequelae include the inadequate use of vaccination for prevention and the lack of treatment for many Filipinos. Because without medical monitoring and treatment of CHB the risk of progression to liver failure and death is 25-30%, the ultimate medical and societal costs will be very high if the Philippines fails to properly address hepatitis B infection. It will be very important to move forward with programs that can help to ensure universal vaccination of newborns, screening and vaccination nationwide, and monitoring and treatment for CHB persons. It will also be crucial to address transmission of HBV in the health-care setting (via contaminated needles and syringes and inadequately sterilized hospital equipment) and via injection drug use and tattooing. Because of the relatively low average per capita income and the lack of coverage by PhilHealth of outpatient visits and medications, there is an urgent need to move forward with a nationally supported program that includes education for both the general public and health-care workers on liver disease and screening for hepatitis viruses, followed by, as appropriate, vaccination or treatment, with expanded government coverage for these for all those who could not otherwise afford it.
引用
收藏
页码:945 / 952
页数:8
相关论文
共 61 条
[1]  
[Anonymous], 2012, HLTH SERVICE DELIVER
[2]  
Basaca-Sevilla V, 1981, PHILIPPINE J MICROBI, V10, P83
[3]  
BEASLEY RP, 1983, LANCET, V2, P1099
[4]   INCIDENCE OF HEPATITIS-B VIRUS-INFECTIONS IN PRESCHOOL-CHILDREN IN TAIWAN [J].
BEASLEY, RP ;
HWANG, LY ;
LIN, CC ;
LEU, ML ;
STEVENS, CE ;
SZMUNESS, W ;
CHEN, KP .
JOURNAL OF INFECTIOUS DISEASES, 1982, 146 (02) :198-204
[5]   Concentrations of Tenofovir and Emtricitabine in Breast Milk of HIV-1-Infected Women in Abidjan, Cote d'Ivoire, in the ANRS 12109 TEmAA Study, Step 2 [J].
Benaboud, Sihem ;
Pruvost, Alain ;
Coffie, Patrick A. ;
Ekouevi, Didier K. ;
Urien, Saik ;
Arrive, Elise ;
Blanche, Stephane ;
Theodoro, Frederic ;
Avit, Divine ;
Dabis, Francois ;
Treluyer, Jean-Marc ;
Hirt, Deborah .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (03) :1315-1317
[6]   Hepatitis B virus and human immunodeficiency virus drugs in pregnancy: Findings from the Antiretroviral Pregnancy Registry [J].
Brown, Robert S., Jr. ;
Verna, Elizabeth C. ;
Pereira, Marcus R. ;
Tilson, Hugh H. ;
Aguilar, Christopher ;
Leu, Cheng-Shiun ;
Buti, Maria ;
Fagan, Elizabeth A. .
JOURNAL OF HEPATOLOGY, 2012, 57 (05) :953-959
[7]   Natural history of chronic hepatitis B virus infection in adults with emphasis on the occurrence of cirrhosis and hepatocellular carcinoma [J].
Chu, CM .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2000, 15 :E25-E30
[8]   Progress in the control of hepatitis B infection in the Western Pacific Region [J].
Clements, CJ ;
Yang, BP ;
Crouch, A ;
Hipgrave, D ;
Mansoor, O ;
Nelson, CB ;
Treleaven, S ;
van Konkelenberg, R ;
Wiersma, S .
VACCINE, 2006, 24 (12) :1975-1982
[9]   AGE-RELATED AND SEX-RELATED STUDY OF HEPATITIS-B VIRUS CHRONIC CARRIER STATE IN INFANTS FROM AN ENDEMIC AREA (SENEGAL) [J].
COURSAGET, P ;
YVONNET, B ;
CHOTARD, J ;
VINCELOT, P ;
SARR, M ;
DIOUF, C ;
CHIRON, JP ;
DIOPMAR, I .
JOURNAL OF MEDICAL VIROLOGY, 1987, 22 (01) :1-5
[10]  
Dalmacio LM, 2005, PHILIPP J INTERN MED, V43, P301