Comparative Examination of Androgen Receptor Reactivity for Differential Diagnosis of Sebaceous Carcinoma From Squamous Cell and Basal Cell Carcinoma

被引：36

作者：

Asadi-Amoli, Fahimeh ^{[1
,2
]}

Khoshnevis, Farid ^{[1
]}

Haeri, Hayedeh ^{[1
]}

Jahanzad, Issa ^{[1
,3
]}

Pazira, Reza ^{[1
]}

Shahsiah, Reza ^{[1
,3
]}

机构：

[1] Univ Tehran Med Sci, Dept Pathol, Tehran, Iran

[2] Univ Tehran Med Sci, Farabi Eye Hosp, Tehran, Iran

[3] Univ Tehran Med Sci, Canc Res Inst, Tehran, Iran

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2010年 / 134卷 / 01期

关键词：

Sebaceous carcinoma; Squamous cell carcinoma; Basal cell carcinoma; Androgen receptor; Immunohistochemistry; EXPRESSION; SKIN;

D O I：

10.1309/AJCP89LYTPNVOBAP

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Sebaceous carcinoma (SEB) is the most important malignant tumor of the eyelid. Early diagnosis and proper treatment significantly improve the outcome. SEB should be differentiated histopathologically from basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). In this study, the expression of androgen receptor (AR) in SEB, SCC, and BCC was evaluated. AR was positive in all 19 SEB cases. Of 18 BCCs, 6 (33%) showed focal nuclear immunoreactivity. The 18 SCCs showed no nuclear immunoreactivity. AR is a sensitive marker for SEB, especially in less differentiated tumors. Along with other markers and morphologic features, AR can be helpful in the diagnosis of SEB and its differentiation from SCC and BCC.

引用

页码：22 / 26

页数：5

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