HIGH-CONTENT SCREENS Giving Rho(d) directions

被引：0

作者：

Muellner, Markus K. ^{[1
]}

Nijman, Sebastian M. B. ^{[1
]}

机构：

[1] Austrian Acad Sci, CeMM, A-1010 Vienna, Austria

来源：

NATURE CHEMICAL BIOLOGY | 2010年 / 6卷 / 06期

关键词：

D O I：

10.1038/nchembio.373

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Drugs identified in high-content screens are often difficult to link to the cellular target, especially when multiple signaling pathways impinge on the phenotypic endpoint. A chemical-genetic approach in fruit fly cells now greatly improves the prioritization of drug hits by directing the screen toward a single pathway.

引用

页码：397 / 398

页数：2

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