Physical function as a prognostic biomarker among cancer survivors

被引：95
作者：
Brown, J. C. [1 ]
Harhay, M. O. [1 ]
Harhay, M. N. [1 ,2 ]
机构：
[1] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Renal Electrolyte & Hypertens Div, Philadelphia, PA 19104 USA
来源：
BRITISH JOURNAL OF CANCER | 2015年 / 112卷 / 01期
关键词：
NHANES III; population-based; disability; short physical performance battery; gait speed; LOWER-EXTREMITY FUNCTION; OLDER-ADULTS; SUBSEQUENT DISABILITY; LIFE-STYLE; PERFORMANCE-MEASURES; GAIT SPEED; INTERVENTION; PREVALENCE; NUTRITION; MORTALITY;
D O I：
10.1038/bjc.2014.568
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: We tested the hypothesis that objectively measured physical function predicts mortality among cancer survivors. Methods: We assessed objectively measured physical function including the short physical performance battery (SPPB) and fast walk speed in older adult cancer survivors. Results: Among 413 cancer survivors, 315 (76%) died during a median follow-up of 11.0 years. In multivariable-adjusted analyses, each 1-unit increase in the SPPB score and 0.1ms(-1) increase in fast walk speed predicted a 12% reduction in mortality (hazard ratio (HR): 0.88 (95% confidence interval (CI): 0.82-0.94); P<0.001, and HR: 0.88 (95% CI: 0.82-0.96); P = 0.003, respectively). Conclusions: Objectively measured physical function may predict mortality among cancer survivors.
引用
收藏
页码：194 / 198
页数：5
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