Physical function as a prognostic biomarker among cancer survivors

被引：97

作者：

Brown, J. C. ^{[1
]}

Harhay, M. O. ^{[1
]}

Harhay, M. N. ^{[1
,2
]}

机构：

[1] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Renal Electrolyte & Hypertens Div, Philadelphia, PA 19104 USA

来源：

BRITISH JOURNAL OF CANCER | 2015年 / 112卷 / 01期

关键词：

NHANES III; population-based; disability; short physical performance battery; gait speed; LOWER-EXTREMITY FUNCTION; OLDER-ADULTS; SUBSEQUENT DISABILITY; LIFE-STYLE; PERFORMANCE-MEASURES; GAIT SPEED; INTERVENTION; PREVALENCE; NUTRITION; MORTALITY;

D O I：

10.1038/bjc.2014.568

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: We tested the hypothesis that objectively measured physical function predicts mortality among cancer survivors. Methods: We assessed objectively measured physical function including the short physical performance battery (SPPB) and fast walk speed in older adult cancer survivors. Results: Among 413 cancer survivors, 315 (76%) died during a median follow-up of 11.0 years. In multivariable-adjusted analyses, each 1-unit increase in the SPPB score and 0.1ms(-1) increase in fast walk speed predicted a 12% reduction in mortality (hazard ratio (HR): 0.88 (95% confidence interval (CI): 0.82-0.94); P<0.001, and HR: 0.88 (95% CI: 0.82-0.96); P = 0.003, respectively). Conclusions: Objectively measured physical function may predict mortality among cancer survivors.

引用

页码：194 / 198

页数：5

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