Acidosis reduces neuronal apoptosis

被引：40
作者：
Xu, LJ
Glassford, AJM
Giaccia, AJ
Giffard, RG
机构：
[1] Stanford Univ, Sch Med, Dept Anesthesia, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Radiat Oncol, Stanford, CA 94305 USA
来源：
NEUROREPORT | 1998年 / 9卷 / 05期
关键词：
acidosis; apoptosis; neuron; p53; primary culture; serum deprivation;
D O I：
10.1097/00001756-199803300-00021
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
ACIDOSIS is a well established concomitant of tissue ischemia. Acidosis in the pH range 6.0-7.0 is seen in cerebral ischemia and within solid tumors. Extracellular acidosis of pH 6.0 and 6.4 provided essentially complete protection from 48 h serum deprivation induced apoptotic death of cultured primary murine neurons. We tested the effect of p53 using transformed mouse embryo fibroblasts of either p53+/+ or p53(-/-) genotype. Both were markedly protected from serum deprivation by acidity. Hypoxia induced fibroblast injury was also reduced at pH 6.8. Lower pH resulted in a shift from apoptotic to necrotic morphology after 42 h hypoxia. Acidosis reduces apoptosis of both normal and transformed cells, irrespective of p53 status. (C) 1998 Rapid Science Ltd.
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收藏
页码：875 / 879
页数：5
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