Inhibition of the B cell by CD22: A requirement for Lyn

被引：163

作者：

Smith, KGC

Tarlinton, DM

Doody, GM

Hibbs, ML

Fearon, DT ^{[1
]}

机构：

[1] Univ Cambridge, Sch Clin Med, Dept Med, Wellcome Trust Immunol Unit, Cambridge CB2 2SP, England

[2] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

[3] Royal Melbourne Hosp, Ludwig Inst Canc Res, Tumor Biol Branch, Parkville, Vic 3050, Australia

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1998年 / 187卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1084/jem.187.5.807

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mice in which the Lyn, Cd22, or Shp-1 gene has been disrupted have hyperactive B cells and autoantibodies. We find that in the absence of Lyn, the ability of CD22 to become tyrosine phosphorylated after Ligation of mIg, to recruit SHP-1, and to suppress mig-induced elevation of intracellular [Ca2+] is lost. Therefore, Lyn is required for the SHP-1-mediated B cell suppressive function of CD22, accounting for similarities in the phenotypes of these mice.

引用

页码：807 / 811

页数：5

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