PGx: Putting Peptides to BED

被引:15
作者
Askenazi, Manor [1 ]
Ruggles, Kelly V. [2 ]
Fenyoe, David [2 ]
机构
[1] Biomed Hosting LLC, 33 Lewis Ave, Arlington, MA 02474 USA
[2] NYU, Langone Med Ctr, 227 East 30th St, New York, NY 10016 USA
基金
美国国家卫生研究院;
关键词
proteogenomics; proteogenomic mapping proteomics; MASS-SPECTROMETRY; TANDEM; TRANSCRIPTOMES; DATABASES; BROWSER; GENES;
D O I
10.1021/acs.jproteome.5b00870
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Every molecular player in the cast of biology's central dogma is being sequenced and quantified with increasing ease and coverage. To bring the resulting genomic, transcriptomic, and proteomic data sets into coherence, tools must be developed that do not constrain data acquisition and analytics in any way but rather provide simple links across previously acquired data sets with minimal preprocessing and hassle. Here we present such a tool: PGx, which supports proteogenomic integration of mass spectrometry proteomics data with next -generation sequencing by mapping identified peptides onto their putative genomic coordinates.
引用
收藏
页码:795 / 799
页数:5
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