MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery

被引：107
作者：
Chen, Wei-Hai
Luo, Guo-Feng
Lei, Qi
Jia, Hui-Zhen
Hong, Sheng
Wang, Qing-Rong [1 ]
Zhuo, Ren-Xi
Zhang, Xian-Zheng
机构：
[1] Wuhan Univ, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 03期
基金：
中国国家自然科学基金;
关键词：
MATRIX METALLOPROTEINASES; CELL DEATH; THERAPY; NANOCARRIERS; DESIGN; NANOPARTICLES; STRATEGIES; RELEASE; PEPTIDE;
D O I：
10.1039/c4cc07563c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Multifunctional Biotin-PEG-b-PLL(Mal)-peptide-DOX polymeric micelles were prepared to selectively eliminate cancer cells. The micelles were able to enhance cancer cell uptake via the receptor-mediated endocytosis and respond to the stimulus of cancer cell excessive secreted protease MMP-2 to release the anticancer drug and induce apoptosis of cancer cells in a targeted manner.
引用
收藏
页码：465 / 468
页数：4
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