Plin5, a New Target in Diabetic Cardiomyopathy

被引：15

作者：

Cui, Xiangning ^{[1
]}

Wang, Jingwu ^{[2
]}

Zhang, Yang ^{[3
]}

Wei, Jianliang ^{[4
]}

Wang, Yan ^{[3
]}

机构：

[1] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Cardiovasc, Beijing 100053, Peoples R China

[2] Shandong Univ Tradit Chinese Med, Clin Educ Div, Jinan 250000, Shandong, Peoples R China

[3] Shandong Univ Tradit Chinese Med, Clin Med Sch 1, Jinan 250000, Shandong, Peoples R China

[4] Shandong Univ Tradit Chinese Med, Cardiovasc Dept, Affiliated Hosp, Jinan 250000, Shandong, Peoples R China

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2022年 / 2022卷

基金：

中国国家自然科学基金;

关键词：

ENDOPLASMIC-RETICULUM STRESS; PANCREATIC BETA-CELLS; ACTIVATED PROTEIN-KINASE; LIPID DROPLET PROTEIN; FATTY-ACID RECEPTOR; MYOCARDIAL TRIGLYCERIDE CONTENT; INDUCED INSULIN-RESISTANCE; PERILIPIN; SKELETAL-MUSCLE; OXIDATIVE STRESS;

D O I：

10.1155/2022/2122856

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Abnormal lipid accumulation is commonly observed in diabetic cardiomyopathy (DC), which can create a lipotoxic microenvironment and damage cardiomyocytes. Lipid toxicity is an important pathogenic factor due to abnormal lipid accumulation in DC. As a lipid droplet (LD) decomposition barrier, Plin5 can protect LDs from lipase decomposition and regulate lipid metabolism, which is involved in the occurrence and development of cardiovascular diseases. In recent years, studies have shown that Plin5 expression is involved in the pathogenesis of DC lipid toxicity, such as oxidative stress, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and insulin resistance (IR) and has become a key target of DC research. Therefore, understanding the relationship between Plin5 and DC progression as well as the mechanism of this process is crucial for developing new therapeutic approaches and exploring new therapeutic targets. This review is aimed at exploring the latest findings and roles of Plin5 in lipid metabolism and DC-related pathogenesis, to explore possible clinical intervention approaches.

引用

页数：20

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