Pulmonary Alveolar Proteinosis with Ulcerative Colitis

被引：1
作者：
Sakamoto, Noriho [1 ]
Nakashima, Shota [1 ]
Ishimoto, Hiroshi [1 ]
Kakugawa, Tomoyuki [1 ]
Hara, Atsuko [1 ]
Yura, Hirokazu [1 ]
Miyamura, Takuto [1 ]
Nakamichi, Seiko [2 ]
Obase, Yasushi [1 ]
Ishimatsu, Yuji [3 ]
Mukae, Hiroshi [1 ]
机构：
[1] Nagasaki Univ, Dept Resp Med, Unit Basic Med Sci, Grad Sch Biomed Sci, Nagasaki, Nagasaki, Japan
[2] Nagasaki Univ, Dept Gen Med, Unit Basic Med Sci, Grad Sch Biomed Sci, Nagasaki, Nagasaki, Japan
[3] Nagasaki Univ, Dept Hlth Sci, Unit Rehabil Sci, Grad Sch Biomed Sci, Nagasaki, Nagasaki, Japan
来源：
INTERNAL MEDICINE | 2018年 / 57卷 / 18期
基金：
日本学术振兴会;
关键词：
anti-GM-CSF antibody; Crohn's disease; inflammatory bowel disease; COLONY-STIMULATING FACTOR; INFLAMMATORY-BOWEL-DISEASE; CYTOKINE GM-CSF; FACTOR AUTOANTIBODIES; CROHNS-DISEASE; MANIFESTATIONS; IMMUNE; COHORT; CELLS;
D O I：
10.2169/internalmedicine.0555-17
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 65-year-old Japanese man was referred to our hospital for the further assessment of cough and dyspnea. He had a history of ulcerative colitis for which he was receiving treatment. Chest computed tomography showed a crazy-paving pattern. His bronchoalveolar lavage fluid had a milky appearance, and a transbronchial lung biopsy specimen revealed acellular periodic acid-Schiff stain-positive bodies. The serum antigranulocyte macrophage-colony stimulating factor (GM-CSF) antibody titer was elevated. The diagnosis was autoimmune pulmonary alveolar proteinosis (PAP). There are few reports of autoimmune PAP in patients with ulcerative colitis. Some reports suggest that PAP and inflammatory bowel disease might have a common pathogenesis involving the anti-GM-CSF antibody.
引用
收藏
页码：2705 / 2708
页数：4
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