Green Synthesized Chitosan/Chitosan Nanoforms/Nanocomposites for Drug Delivery Applications

被引:50
作者
Sivanesan, Iyyakkannu [1 ]
Gopal, Judy [2 ]
Muthu, Manikandan [2 ]
Shin, Juhyun [3 ]
Mari, Selvaraj [4 ]
Oh, Jaewook [3 ]
机构
[1] Konkuk Univ, Dept Bioresources & Food Sci, Seoul 05029, South Korea
[2] Lab Neo Nat Farming, Chunnampet 603401, Tamil Nadu, India
[3] Konkuk Univ, Dept Stem Cell & Regenerat Biotechnol, Seoul 143701, South Korea
[4] Guru Nanak Coll, Dept Chem, Chennai 600042, Tamil Nadu, India
关键词
chitosan; chitosan nanoparticles; synthesis; green synthesis; drug delivery; CHITOSAN-BASED NANOPARTICLES; IRON-OXIDE NANOPARTICLES; DEEP EUTECTIC SOLVENTS; CROSS-LINKED CHITOSAN; CRAB SHELL WASTE; PEN BETA-CHITIN; MOLECULAR-WEIGHT; IN-VITRO; NASAL DELIVERY; IONIC LIQUIDS;
D O I
10.3390/polym13142256
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Chitosan has become a highlighted polymer, gaining paramount importance and research attention. The fact that this valuable polymer can be extracted from food industry-generated shell waste gives it immense value. Chitosan, owing to its biological and physicochemical properties, has become an attractive option for biomedical applications. This review briefly runs through the various methods involved in the preparation of chitosan and chitosan nanoforms. For the first time, we consolidate the available scattered reports on the various attempts towards greens synthesis of chitosan, chitosan nanomaterials, and chitosan nanocomposites. The drug delivery applications of chitosan and its nanoforms have been reviewed. This review points to the lack of systematic research in the area of green synthesis of chitosan. Researchers have been concentrating more on recovering chitosan from marine shell waste through chemical and synthetic processes that generate toxic wastes, rather than working on eco-friendly green processes-this is projected in this review. This review draws the attention of researchers to turn to novel and innovative green processes. More so, there are scarce reports on the application of green synthesized chitosan nanoforms and nanocomposites towards drug delivery applications. This is another area that deserves research focus. These have been speculated and highlighted as future perspectives in this review.
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页数:21
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