Fibroblast growth factor signaling during early vertebrate development

被引：440
作者：
Böttcher, RT [1 ]
Niehrs, C [1 ]
机构：
[1] Deutsch Krebsforschungszentrum, Dept Mol Embryol, D-69120 Heidelberg, Germany
来源：
ENDOCRINE REVIEWS | 2005年 / 26卷 / 01期
关键词：
D O I：
10.1210/er.2003-0040
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Fibroblast growth factors (FGFs) have been implicated in diverse cellular processes including apoptosis, cell survival, chemotaxis, cell adhesion, migration, differentiation, and proliferation. This review presents our current understanding on the roles of FGF signaling, the pathways employed, and its regulation. We focus on FGF signaling during early embryonic processes in vertebrates, such as induction and patterning of the three germ layers as well as its function in the control of morphogenetic movements.
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页码：63 / 77
页数：15
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