Good Cell, Bad Cell: Flow Cytometry Reveals T-cell Subsets Important in HIV Disease

被引：65

作者：

Chattopadhyay, Pratip K. ^{[1
]}

Roederer, Mario ^{[1
]}

机构：

[1] NIAID, Immunotechnol Sect, Vaccine Res Ctr, NIH, Bethesda, MD USA

来源：

CYTOMETRY PART A | 2010年 / 77A卷 / 07期

关键词：

flow cytometry; HIV; T-cells; ACTIVE ANTIRETROVIRAL THERAPY; MULTICENTER AIDS COHORT; CD38; ANTIGEN-EXPRESSION; LYMPHOCYTE-ACTIVATION; PROGRAMMED DEATH-1; IMMUNE ACTIVATION; INFECTED PATIENTS; PD-1; EXPRESSION; HTLV-III/LAV; VIRAL LOAD;

D O I：

10.1002/cyto.a.20905

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Flow cytometry is a key technology in the study of HIV disease. In this article, we review various cellular markers that can be measured in the setting of pathogenesis or vaccination studies, including markers of activation, differentiation, senescence, immune suppression, and function In addition, we discuss important considerations for making these measurements Finally, we examine how flow cytometry studies have taught researchers about the disease process, and the potential for flow cytometry technology to guide treatment decisions and evaluate vaccine candidates in the future Published 2010 Wiley-Liss, Inc dagger

引用

页码：614 / 622

页数：9

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