Dramatic rate enhancement of asymmetric phase-transfer-catalyzed alkylations

被引：60

作者：

Shirakawa, S ^{[1
]}

Yamamoto, K ^{[1
]}

Kitamura, M ^{[1
]}

Ooi, T ^{[1
]}

Maruoka, K ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Kyoto 6068502, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 04期

关键词：

alkylation; amino acids; crown compounds; enantioselectivity; phase-transfer catalysis;

D O I：

10.1002/anie.200462035

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The intervention of crown ethers or achiral quaternary ammonium salts as achiral phase-transfer catalysts (PTCs, see scheme) in a chiral PTC system leads to dramatic rate enhancements in the asymmetric alkylation of glycine derivatives.

引用

页码：625 / 628

页数：4

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