The evaluation of whole-body plethysmography as a semiautomated method for analysis of emesis in the house musk shrew (Suncus murinus)

被引：0
|
作者：
Tashiro, Nobuhiko [1 ]
Kataoka, Masanori [1 ]
Ozawa, Kazunori [1 ]
Ikeda, Takuya [1 ]
机构：
[1] GlaxoSmithKline KK, Tsukuba Res Labs, Lab Anim Sci, Ibaraki, Japan
来源：
JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE | 2007年 / 46卷 / 02期
关键词：
D O I：
暂无
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
We analyzed the cisplatin-induced emetic responses of Suncus murinus by observation of both videorecorded behavior and changes in peak expiratory flow (PEF) as monitored by whole-body plethysmography. Analysis of the PEF data by use of a macro program revealed emesis-related changes in PEE Cisplatin dose-response curves obtained by both methods showed similar emesis profiles. In addition, our PEF-based analytical method could be used to assess emesis changes induced by various other emetogens (veratrine hydrochloride, nicotine bitartrate, and copper sulfate) and confirmed the efficacy of the antiemetic drugs ondansetron, metoclopramide, and GR205171 in the cisplatin-induced emesis model. These results demonstrate that the use of whole-body plethysmography to follow changes in PEF was an effective semiautomated method of assessing emetic responses in Suncus murinus. This novel semiautomated method may provide an objective, sensitive, and efficient way to study emesis in animal models.
引用
收藏
页码：81 / 85
页数：5
相关论文
共 50 条
  • [21] A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew)
    Magdalena Kwiatkowska
    Linda A. Parker
    Page Burton
    Raphael Mechoulam
    Psychopharmacology, 2004, 174 : 254 - 259
  • [22] A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew)
    Kwiatkowska, M
    Parker, LA
    Burton, P
    Mechoulam, R
    PSYCHOPHARMACOLOGY, 2004, 174 (02) : 254 - 259
  • [23] Effects of isolation on aggression in the domesticated house musk shrew (Suncus murinus)
    Kawano, K
    JOURNAL OF ETHOLOGY, 1996, 14 (01) : 77 - 81
  • [24] The force driving mating behavior in the house musk shrew (Suncus murinus)
    Matsuzaki, O
    ZOOLOGICAL SCIENCE, 2002, 19 (08) : 851 - 869
  • [25] Action of prostanoids on the emetic reflex of Suncus murinus (the house musk shrew)
    Kan, KKW
    Jones, RL
    Ngan, MP
    Rudd, JA
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 477 (03) : 247 - 251
  • [26] Regulation of longitudinal esophageal motility in the house musk shrew (Suncus murinus)
    Shiina, Takahiko
    Naitou, Kiyotada
    Nakamori, Hiroyuki
    Sakai, Hiroki
    Shimizu, Yasutake
    AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 2015, 189 : 37 - 42
  • [27] Molecular identification, characterization, and structure analysis of house musk shrew (Suncus murinus) leptin
    Saga, Sayaka
    Sasaki, Noriyasu
    Arai, Toshiro
    JOURNAL OF ADVANCED VETERINARY AND ANIMAL RESEARCH, 2019, 6 (01) : 1 - 8
  • [28] CENTRAL GLP-1 RECEPTORS ARE DIFFERENTIALLY INVOLVED IN EMESIS AND FEEDING CONTROL IN SUNCUS MURINUS (HOUSE MUSK SHREW)
    Chan, Sze Wa
    Lu, Zengbing
    Rudd, John A.
    GASTROENTEROLOGY, 2018, 154 (06) : S753 - S753
  • [29] The Actions of Centrally Administered Nesfatin-1 on Emesis, Feeding, and Locomotor Activity in Suncus murinus (House Musk Shrew)
    Lu, Zengbing
    Cui, Dexuan
    Liu, Julia Yuen Hang
    Jiang, Bin
    Ngan, Man Piu
    Sakata, Ichiro
    Takemi, Shota
    Sakai, Takafumi
    Lin, Ge
    Chan, Sze Wa
    Rudd, John A.
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [30] Synergy Between Cannabidiol, Cannabidiolic Acid, and Δ9-Tetrahydrocannabinol in the Regulation of Emesis in the Suncus Murinus (House Musk Shrew)
    Rock, Erin M.
    Parker, Linda A.
    BEHAVIORAL NEUROSCIENCE, 2015, 129 (03) : 368 - 370
12345