The evaluation of whole-body plethysmography as a semiautomated method for analysis of emesis in the house musk shrew (Suncus murinus)

被引：0
|
作者：
Tashiro, Nobuhiko [1 ]
Kataoka, Masanori [1 ]
Ozawa, Kazunori [1 ]
Ikeda, Takuya [1 ]
机构：
[1] GlaxoSmithKline KK, Tsukuba Res Labs, Lab Anim Sci, Ibaraki, Japan
来源：
JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE | 2007年 / 46卷 / 02期
关键词：
D O I：
暂无
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
We analyzed the cisplatin-induced emetic responses of Suncus murinus by observation of both videorecorded behavior and changes in peak expiratory flow (PEF) as monitored by whole-body plethysmography. Analysis of the PEF data by use of a macro program revealed emesis-related changes in PEE Cisplatin dose-response curves obtained by both methods showed similar emesis profiles. In addition, our PEF-based analytical method could be used to assess emesis changes induced by various other emetogens (veratrine hydrochloride, nicotine bitartrate, and copper sulfate) and confirmed the efficacy of the antiemetic drugs ondansetron, metoclopramide, and GR205171 in the cisplatin-induced emesis model. These results demonstrate that the use of whole-body plethysmography to follow changes in PEF was an effective semiautomated method of assessing emetic responses in Suncus murinus. This novel semiautomated method may provide an objective, sensitive, and efficient way to study emesis in animal models.
引用
收藏
页码：81 / 85
页数：5
相关论文
共 50 条
  • [1] Insights Into Acute and Delayed Cisplatin-Induced Emesis From a Microelectrode Array, Radiotelemetry and Whole-Body Plethysmography Study of Suncus murinus (House Musk Shrew)
    Tu, Longlong
    Liu, Julia Y. H.
    Lu, Zengbing
    Cui, Dexuan
    Ngan, Man P.
    Du, Peng
    Rudd, John A.
    FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [2] Ethanol-induced emesis in the house musk shrew, Suncus murinus
    Chen, Y
    Saito, H
    Matsuki, N
    LIFE SCIENCES, 1996, 60 (4-5) : 253 - 261
  • [3] Potential energetic implications of emesis in the house musk shrew (Suncus murinus)
    Andrews, PLR
    Friedman, MI
    Liu, YL
    Smith, JE
    Sims, DW
    PHYSIOLOGY & BEHAVIOR, 2005, 84 (04) : 519 - 524
  • [4] Genital grooming and emesis induced by vanilloids in Suncus murinus, the house musk shrew
    Rudd, JA
    Wai, MK
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2001, 422 (1-3) : 185 - 195
  • [5] A New Model of Morphine-Induces Emesis in Suncus murinus (House Musk Shrew)
    Liu, Luping
    Lu, Zengbing
    Liu, Yuen Hang Julia
    Hui, Jessica C. M.
    Yang, Lingqing
    Khalid, Aleena
    Ng, Heidi S. H.
    Li, Zitong
    Cui, Dexuan
    Jiang, Bin
    Deng, Yingyi
    Ngan, Man Piu
    Rudd, John Anthony
    BRITISH JOURNAL OF PHARMACOLOGY, 2023, 180 : 1234 - 1235
  • [6] Scopolamine antagonises bethanechol-Induced emesis in Suncus murinus (house musk shrew)
    Chan, S. W.
    Ngan, M. -P.
    Wai, M. K.
    Wong, H. Y.
    Yeung, C. -K.
    Lu, Z.
    Rudd, J.
    NEUROGASTROENTEROLOGY AND MOTILITY, 2014, 26 : 15 - 15
  • [7] Modulation of emesis by fentanyl and opioid receptor antagonists in Suncus murinus (house musk shrew)
    Rudd, JA
    Cheng, CHK
    Naylor, RJ
    Ngan, MP
    Wai, MK
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1999, 374 (01) : 77 - 84
  • [8] Involvement of Hypothalamic Glutamate in Cisplatin-Induced Emesis in Suncus murinus (House Musk Shrew)
    Yamamoto, Kouichi
    Chan, Sze Wa
    Rudd, John A.
    Lin, Ge
    Asano, Keiko
    Yamatodani, Atsushi
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109 (04) : 631 - 634
  • [9] Superovulation induction in the house musk shrew (Suncus murinus)
    Matsuzaki, T
    Matsuzaki, K
    Yokoyama, M
    Yamada, S
    Saito, M
    EXPERIMENTAL ANIMALS, 1997, 46 (03) : 183 - 189
  • [10] An arterially perfused decerebrate preparation of Suncus murinus (house musk shrew) for the study of emesis and swallowing
    Smith, JE
    Paton, JFR
    Andrews, PLR
    EXPERIMENTAL PHYSIOLOGY, 2002, 87 (05) : 563 - 574
12345