Present and future treatment strategies for coronavirus disease 2019

被引:17
|
作者
Elekhnawy, Engy [1 ]
Kamar, Amal Abo [1 ]
Sonbol, Fatma [1 ]
机构
[1] Tanta Univ, Fac Pharm, Pharmaceut Microbiol, Tanta, El Gharbia Gove, Egypt
关键词
COVID-19; SARS-Cov-2; Cytokine storm; Respiratory distress syndrome; SEVERE COVID-19; ANAKINRA; TRIAL;
D O I
10.1186/s43094-021-00238-y
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background The recent pandemic of coronavirus disease 2019 (COVID-19) has resulted in many challenges to the healthcare organizations around the world. Unfortunately, until now, there are no proven effective therapeutic agents against this virus. Main body Several evolving studies suggest repurposing a potential list of drugs which have appropriate pharmacological and therapeutic effects to be used in treating COVID-19 cases. In the present review, we will summarize the potential drugs suggested to be repurposed to be utilized in the treatment of COVID-19 patients like lopinavir-ritonavir, ribavirin, baloxavir marboxil, favipiravir, remdesvir, umifenovir, chloroquine, hydroxychloroquine, azithromycin, corticosteroids, losartan, statins, interferons, nitric oxide, epoprostenol, tocilizumab, siltuximab, sarilumab anakinra, and ruxolitinib. In addition, we discussed the possible future therapeutic regimens based on the recent molecular and genomic discoveries. Conclusion This review could provide beneficial information about the potential current and future treatment strategies to treat the pandemic COVID-19 disease.
引用
收藏
页数:9
相关论文
共 50 条
  • [21] Antiviral Treatment of Coronavirus Disease-2019 Pneumonia
    Radcliffe, Christopher
    Malinis, Maricar
    Azar, Marwan M.
    CLINICS IN CHEST MEDICINE, 2023, 44 (02) : 279 - 297
  • [22] Gender differences in treatment of Coronavirus Disease-2019
    Ambrosino, Immacolata
    Barbagelata, Elena
    Corbi, Graziamaria
    Ciarambino, Tiziana
    Politi, Cecilia
    Moretti, Anna Maria
    MONALDI ARCHIVES FOR CHEST DISEASE, 2020, 90 (04) : 646 - 656
  • [23] Acupuncture Treatment for Coronavirus Disease 2019: A Review Article
    Nurwati, Ida
    Huda, Khairunnisa Nurul
    MEDICAL ACUPUNCTURE, 2021, 33 (01) : 45 - 48
  • [24] The overlooked chamber in coronavirus disease 2019
    Cao, Yunshan
    Zhang, Min
    Guo, Yanqing
    Zhang, Yan
    ESC HEART FAILURE, 2020, 7 (06): : 3483 - 3486
  • [25] Neuropathogenesis of acute coronavirus disease 2019
    Farhadian, Shelli F.
    Seilhean, Danielle
    Spudich, Serena
    CURRENT OPINION IN NEUROLOGY, 2021, 34 (03) : 417 - 422
  • [26] The Pancreas in Coronavirus Disease 2019 Infection
    de Sa, Tiago Correia
    Rocha, Monica
    GASTROENTEROLOGY CLINICS OF NORTH AMERICA, 2023, 52 (01) : 37 - 48
  • [27] Coronavirus Disease-2019 Treatment Strategies Targeting Interleukin-6 Signaling and Herbal Medicine
    Dzobo, Kevin
    Chiririwa, Harry
    Dandara, Collet
    Dzobo, Witness
    OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 2021, 25 (01) : 13 - 22
  • [28] Acute central and peripheral nervous system injury associated with coronavirus disease 2019: recognition and treatment strategies
    Simon, Dennis W.
    Schober, Michelle E.
    CURRENT OPINION IN PEDIATRICS, 2021, 33 (06) : 591 - 596
  • [29] Mesenchymal stem cells: a new front emerges in coronavirus disease 2019 treatment
    Raza, Syed Shadab
    Khan, Mohsin Ali
    CYTOTHERAPY, 2022, 24 (08) : 755 - 766
  • [30] Comparison of Anakinra and Tocilizumab in Anticytokine Therapy in the Treatment of Coronavirus Disease-2019
    Ozkan, Feyza
    Sari, Suleyman
    INDIAN JOURNAL OF CRITICAL CARE MEDICINE, 2022, 26 (10) : 1091 - 1098