Reduced sensitivity of the renal vasculature to angiotensin II in young rats: the role of the angiotensin type 2 receptor

被引：8

作者：

Brown, Russell D. ^{[1
]}

Hilliard, Lucinda M. ^{[1
]}

Mirabito, Katrina M. ^{[1
]}

Firth, Laura C. ^{[1
]}

Moritz, Karen M. ^{[2
]}

Evans, Roger G. ^{[1
]}

Denton, Kate M. ^{[1
]}

机构：

[1] Monash Univ, Dept Physiol, Melbourne, Vic 3168, Australia

[2] Univ Queensland, Sch Biomed Sci, Brisbane, Qld, Australia

来源：

PEDIATRIC RESEARCH | 2014年 / 76卷 / 05期

基金：

英国医学研究理事会;

关键词：

NITRIC-OXIDE SYNTHASE; CONSCIOUS LAMBS; GENE-EXPRESSION; AT(2) RECEPTOR; FEMALE RATS; THERAPEUTIC TARGET; BLOOD-FLOW; ONTOGENY; HYPERTENSION; RENIN;

D O I：

10.1038/pr.2014.121

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

BACKGROUND: The angiotensin type-2 receptor (AT(2)R) opposes the vasoconstrictor actions of angiotensin II (AngII) mediated through the angiotensin type-1 receptor (AT,R). Renal AT2R levels are high during fetal life, but decrease significantly during postnatal maturation. To provide insight into the functional role of the AT2R in the kidney during postnatal development, we investigated the effects of AT2R antagonism on cardiovascular responses to AngII in young and adult male rats. METHODS: In anesthetized 3- and 6-wk-old male Sprague-Dawley rats, mean arterial pressure (MAP) and renal blood flow (RBF) were measured in response to AngII in the presence of vehicle treatment or AT2R blockade with PD123319. RESULTS:The pressor effect of AngII and associated reduction in RBF were significantly less in 3-wk- than 6-wk-old rats. AT2R blockade potentiated the reduction in RBF in response to AngII in 3-wk-old rats only. CONCLUSION: In young rats, the AT2R modulates the response to AngII, blunting renal vasoconstriction. This effect is attenuated with age in association with a developmental reduction in renal AT2R expression. These findings may have implications for the development of novel therapies that target the renin-angiotensin system for the improvement of renal function in term and, in particular, preterm infants.

引用

页码：448 / 452

页数：5

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