CRABP1 in Non-Canonical Activities of Retinoic Acid in Health and Diseases

被引：15

作者：

Nhieu, Jennifer ^{[1
]}

Lin, Yu-Lung ^{[1
]}

Wei, Li-Na ^{[1
]}

机构：

[1] Univ Minnesota, Dept Pharmacol, Minneapolis, MN 55455 USA

来源：

NUTRIENTS | 2022年 / 14卷 / 07期

关键词：

CRABP1; retinoic acid; neurodegeneration; inflammation; metabolism; cancer; human disease; non-canonical; MAPK; CAMKII; BINDING-PROTEIN-I; CELL-PROLIFERATION; SKELETAL-MUSCLE; WILD-TYPE; EXPRESSION; RECEPTOR; DIFFERENTIATION; RESISTANCE; GENE; LOCALIZATION;

D O I：

10.3390/nu14071528

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

In this review, we discuss the emerging role of Cellular Retinoic Acid Binding Protein 1 (CRABP1) as a mediator of non-canonical activities of retinoic acid (RA) and relevance to human diseases. We first discuss the role of CRABP1 in regulating MAPK activities and its implication in stem cell proliferation, cancers, adipocyte health, and neuro-immune regulation. We then discuss an additional role of CRABP1 in regulating CaMKII activities, and its implication in heart and motor neuron diseases. Through molecular and genetic studies of Crabp1 knockout (CKO) mouse and culture models, it is established that CRABP1 forms complexes with specific signaling molecules to function as RA-regulated signalsomes in a cell context-dependent manner. Gene expression data and CRABP1 gene single nucleotide polymorphisms (SNPs) of human cancer, neurodegeneration, and immune disease patients implicate the potential association of abnormality in CRABP1 with human diseases. Finally, therapeutic strategies for managing certain human diseases by targeting CRABP1 are discussed.

引用

页数：15

共 117 条

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