Impact of microRNA Regulated Macrophage Actions on Adipose Tissue Function in Obesity

被引：9

作者：

Matz, Alyssa ^{[1
]}

Qu, Lili ^{[1
]}

Karlinsey, Keaton ^{[1
]}

Zhou, Beiyan ^{[1
,2
]}

机构：

[1] Univ Connecticut, Sch Med, Dept Immunol, Farmington, CT 06030 USA

[2] Univ Connecticut, Inst Syst Gen, Farmington, CT 06030 USA

来源：

CELLS | 2022年 / 11卷 / 08期

基金：

美国国家卫生研究院;

关键词：

obesity; immune response; macrophage; microRNA; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; TNF-ALPHA; INFLAMMATORY MACROPHAGES; STRUCTURAL DETERMINANTS; INSULIN-RESISTANCE; CHOLESTEROL EFFLUX; LIPID-METABOLISM; ANALYSIS REVEALS; RNA RECOGNITION;

D O I：

10.3390/cells11081336

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Obesity-induced adipose tissue dysfunction is bolstered by chronic, low-grade inflammation and impairs systemic metabolic health. Adipose tissue macrophages (ATMs) perpetuate local inflammation but are crucial to adipose tissue homeostasis, exerting heterogeneous, niche-specific functions. Diversified macrophage actions are shaped through finely regulated factors, including microRNAs, which post-transcriptionally alter macrophage activation. Numerous studies have highlighted microRNAs' importance to immune function and potential as inflammation-modulatory. This review summarizes current knowledge of regulatory networks governed by microRNAs in ATMs in white adipose tissue under obesity stress.

引用

页数：16

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