Genomic Imprinting in the New Omics Era: A Model for Systems-Level Approaches

被引：8
作者：
Hubert, Jean-Noel [1 ]
Demars, Julie [1 ]
机构：
[1] Univ Toulouse, ENVT, INRAE, GenPhySE, F-31326 Castanet Tolosan, France
来源：
FRONTIERS IN GENETICS | 2022年 / 13卷
关键词：
imprintome; allele-specific expression; differentially methylated region; imprinted control region; noncoding RNA; EXTRACELLULAR-MATRIX GENES; DNA METHYLATION; MICRORNAS ANTAGONIZE; BINDING-SITES; MOUSE; CHROMATIN; GROWTH; EXPRESSION; REVEALS; ALLELE;
D O I：
10.3389/fgene.2022.838534
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Genomic imprinting represents a noteworthy inheritance mechanism leading to allele-specific regulations dependent of the parental origin. Imprinted loci are especially involved in essential mammalian functions related to growth, development and behavior. In this mini-review, we first offer a summary of current representations associated with genomic imprinting through key results of the three last decades. We then outline new perspectives allowed by the spread of new omics technologies tackling various interacting levels of imprinting regulations, including genomics, transcriptomics and epigenomics. We finally discuss the expected contribution of new omics data to unresolved big questions in the field.
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页数：9
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