Highly Efficient RhI-Catalyzed Asymmetric Hydrogenation of β-Amino Acrylonitriles

被引：20

作者：

Ma, Miaofeng ^{[1
,2
,3
]}

Hou, Guohua ^{[2
,3
]}

Sun, Tian ^{[2
,3
]}

Zhang, Xiaowei ^{[2
,3
]}

Li, Wei ^{[2
,3
]}

Wang, Junru ^{[1
]}

Zhang, Xumu ^{[2
,3
]}

机构：

[1] NW A&F Univ, Coll Sci, Yangling 712100, Shaanxi, Peoples R China

[2] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

[3] Rutgers State Univ, Dept Pharmaceut Chem, Piscataway, NJ 08854 USA

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 18期

基金：

美国国家卫生研究院;

关键词：

acrylonitriles; enantioselectivity; hydrogenation; P ligands; rhodium; ALPHA; BETA-UNSATURATED NITRILES; ENANTIOSELECTIVE HYDROGENATION; STEREOSELECTIVE-SYNTHESIS; COOPERATIVE CATALYSIS; ACIDS; AZIRIDINES; BASE; CYANOMETHYLATION; COMPLEX; IMINES;

D O I：

10.1002/chem.201000325

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) It takes two to TangPhos: β-Amino acrylonitriles can be readily prepared from acetonitriles. Both of the E/Z isomers undergo hydrogenation with excellent enantioselectivity by using the Rh-TangPhos (TangPhos = l, 1'-ditert-butyl-(2, 2')-diphospholane) catalyst system. The products, chiral β-amino nitriles, are valuable chiral building blocks for many drugs. © 2010 Wiley-VCH Verlag GmbH&Co. KGaA.

引用

页码：5301 / 5304

页数：4

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