Circulating microRNA-21 (MIR-21) and phosphatase and tensin homolog (PTEN) are promising novel biomarkers for detection of oral squamous cell carcinoma

被引：48

作者：

Ren, WenHao ^{[1
]}

Qiang, Cui ^{[1
]}

Gao, Ling ^{[1
,2
]}

Li, Shao-Ming ^{[1
]}

Zhang, Lin-Mei ^{[1
]}

Wang, Xiao-Long ^{[1
]}

Dong, Jian-Wei ^{[1
]}

Chen, Cheng ^{[1
]}

Liu, Chang-Yang ^{[1
]}

Zhi, Ke-Qian ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Coll Stomatol, Dept Oral & Maxillofacial Surg, Xian 710004, ShaanXi, Peoples R China

[2] Xi An Jiao Tong Univ, Coll Med, Key Lab Environm & Genes Related Dis, Xian 710004, ShaanXi, Peoples R China

来源：

BIOMARKERS | 2014年 / 19卷 / 07期

基金：

高等学校博士学科点专项科研基金;

关键词：

Circulating biomarkers; MIR-21; OSCC; PTEN; LUNG-CANCER; GASTRIC-CANCER; BREAST-CANCER; EXPRESSION; SERUM; HEAD; NECK; DIAGNOSIS; GROWTH; SIGNATURES;

D O I：

10.3109/1354750X.2014.955059

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The purpose of this study was to investigate the potential of the blood levels of MIR-21 and PTEN as novel biomarkers for oral squamous cell carcinoma (OSCC). We initially detected MIR-21 and PTEN using real-time RT-PCR from 90 blood samples and then compared their results with expression in cancer tissues from 10 OSCC patients. Finally, we examined the relationship between these markers and clinical parameters. Blood MIR-21 and PTEN had significant diagnostic value for OSCC and, to an extent, correlated with the expression level of tumour MIR-21 and PTEN. In addition, they were associated with differentiation and nodal status. Thus circulating MIR-21 and PTEN might represent new complementary tumour markers for OSCC.

引用

页码：590 / 596

页数：7

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