LncRNA CADM1-AS1 serves as a new prognostic biomarker for gastric cancer

被引：16
作者：
Shi, X. -Y. [1 ]
Sun, Y. -Z. [1 ]
Li, M. [2 ]
Li, H. -Y. [3 ]
机构：
[1] Children & Womens Healthcare Laiwu City, Dept Lab Med, Laiwu, Peoples R China
[2] Linqu Cty Ctr Dis Prevent & Control, Dept Lab Med, Weifang, Peoples R China
[3] Weifang Peoples Hosp, Dept Gastroenterol, Weifang, Peoples R China
来源：
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2019年 / 23卷
关键词：
Gastric cancer; Long non-coding RNA CADM1-AS1 (lncRNA CADM1-AS1); Prognosis; LONG NONCODING RNA; POOR-PROGNOSIS; DECREASED EXPRESSION; GENE; PREDICTS;
D O I：
10.26355/eurrev_201908_18652
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
OBJECTIVE: To investigate the expression of the long non-coding RNA CADM1-AS1 (lncRNA CADM1-AS1) in gastric cancer and its clinical significance. PATIENTS AND METHODS: The real time fluorescence quantitative polymerase chain reaction (qRT-PCR) was performed to detect the expression difference of lncRNA CADM1-AS1 between gastric cancer and its adjacent normal tissues. Then, the correlation between the expression of CADM1-AS1 in gastric cancer and the clinicopathological characteristics was analyzed by the Chi-square test. Moreover, the potential of lncRNA CADM1-AS1 in predicting the prognosis of patients with GC after the operation was assessed by the Log-rank test and the Cox's proportional hazards regression model. RESULTS: The expression of lncRNA CADM1-AS1 was significantly decreased in tumor tissues. According to the mean expression of lncRNA CADM1-AS1, the patients were divided into a high expression group and a low expression group, and the expression of lncRNA CADM1-AS1 in gastric cancer was significantly correlated with tumor differentiation, N stage, M stage, and TNM stage. Moreover, the gastric cancer patients with higher expression of lncRNA CADM1-AS1 had a statistically better overall survival (OS) time and progression-free survival (PFS) time. In univariate analyses and multivariate analyses, the expression of lncRNA CADM1-AS1 was an independent prognosis index of patients with gastric cancer. CONCLUSIONS: LncRNA CADM1-AS1 might be a new prognostic biomarker for gastric cancer.
引用
收藏
页码：232 / 238
页数：7
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