A hydraulic instability drives the cell death decision in the nematode germline

被引:37
作者
Chartier, Nicolas T. [1 ]
Mukherjee, Arghyadip [2 ,3 ,4 ]
Pfanzelter, Julia [1 ,2 ]
Furthauer, Sebastian [5 ]
Larson, Ben T. [6 ,7 ]
Fritsch, Anatol W. [2 ]
Amini, Rana [2 ]
Kreysing, Moritz [2 ,4 ,8 ]
Julicher, Frank [3 ,4 ,8 ]
Grill, Stephan W. [1 ,2 ,4 ,8 ]
机构
[1] Tech Univ Dresden, Biotechnol Ctr, Dresden, Germany
[2] Max Planck Inst Mol Cell Biol & Genet MPI CBG, Dresden, Germany
[3] Max Planck Inst Phys Complex Syst MPI PKS, Dresden, Germany
[4] Ctr Syst Biol Dresden, Dresden, Germany
[5] Flatiron Inst, Ctr Computat Biol, New York, NY USA
[6] Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA
[7] Univ Calif Berkeley, Biophys Grad Grp, Berkeley, CA 94720 USA
[8] Tech Univ Dresden, Phys Life, Cluster Excellence, Dresden, Germany
基金
欧洲研究理事会; 美国国家科学基金会;
关键词
ELEGANS; POSITION;
D O I
10.1038/s41567-021-01235-x
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
Oocytes are large cells that develop into an embryo upon fertilization(1). As interconnected germ cells mature into oocytes, some of them grow-typically at the expense of others that undergo cell death(2-4). We present evidence that in the nematode Caenorhabditis elegans, this cell-fate decision is mechanical and related to tissue hydraulics. An analysis of germ cell volumes and material fluxes identifies a hydraulic instability that amplifies volume differences and causes some germ cells to grow and others to shrink, a phenomenon that is related to the two-balloon instability(5). Shrinking germ cells are extruded and they die, as we demonstrate by artificially reducing germ cell volumes via thermoviscous pumping(6). Our work reveals a hydraulic symmetry-breaking transition central to the decision between life and death in the nematode germline.
引用
收藏
页码:920 / +
页数:16
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