Osteopontin is Increased in the Cerebrospinal Fluid of Patients with Alzheimer's Disease and Its Levels Correlate with Cognitive Decline

被引：96

作者：

Comi, Cristoforo ^{[1
,2
,5
]}

Carecchio, Miryam ^{[1
]}

Chiocchetti, Annalisa ^{[3
,5
]}

Nicola, Stefania ^{[3
,5
]}

Galimberti, Daniela ^{[4
]}

Fenoglio, Chiara ^{[4
]}

Cappellano, Giuseppe ^{[3
,5
]}

Monaco, Francesco ^{[1
,5
]}

Scarpini, Elio ^{[4
]}

Dianzani, Umberto ^{[3
,5
]}

机构：

[1] A Avogadro Univ Eastern Piedmont, Dept Neurol, Maggiore Hosp, Novara, Italy

[2] Neurorehabil Inst ML Novarese, Moncrivello, VC, Italy

[3] A Avogadro Univ Eastern Piedmont, Dept Med Sci, Maggiore Hosp, Novara, Italy

[4] Univ Milan, Dino Ferrari Ctr, Dept Neurol Sci, IRCCS Osped Maggiore Policlin, Milan, Italy

[5] A Avogadro Univ Eastern Piedmont, IRCAD, Novara, Italy

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 19卷 / 04期

关键词：

Disease progression; early Alzheimer's disease; Eta-1; microglia; neuroinflammation; FRONTOTEMPORAL LOBAR DEGENERATION; PARKINSONS-DISEASE; PROGRESSION; IMPAIRMENT; INFLAMMATION; BIOMARKERS; EXPRESSION; CRITERIA; BRAIN;

D O I：

10.3233/JAD-2010-1309

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Inflammation is believed to play a role in Alzheimer's disease (AD). Osteopontin (OPN) is a molecule involved in macrophage recruitment and activation and implicated in neurodegeneration. In order to elucidate the role of OPN in AD, we evaluated its levels in serum and cerebrospinal fluid (CSF) of 67 AD patients, 46 frontotemporal dementia (FTD) patients, and 69 controls. We found that OPN levels: i) are significantly increased in the CSF of AD patients; ii) correlate with MMSE score; and iii) are higher in the early disease phases (<= 2 years). These findings support a role of OPN in AD pathogenesis.

引用

页码：1143 / 1148

页数：6

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