SOCS1 and its Potential Clinical Role in Tumor

被引：33

作者：

Ying, Jie ^{[1
]}

Qiu, Xiaoyan ^{[1
]}

Lu, Yu ^{[1
]}

Zhang, Miaomiao ^{[1
]}

机构：

[1] Xuyi Peoples Hosp, Dept Clin Res Ctr, 28 Hongwu Rd, Xuyi 211700, Jiangsu, Peoples R China

来源：

PATHOLOGY & ONCOLOGY RESEARCH | 2019年 / 25卷 / 04期

关键词：

SOCS1; Cell signaling; Ubiquitination; Tumors; TOLL-LIKE RECEPTORS; CYTOKINE SIGNALING-1; GENE-EXPRESSION; DENDRITIC CELLS; PROMOTER METHYLATION; SH2; DOMAIN; SUPPRESSOR; BOX; INHIBITION; INDUCTION;

D O I：

10.1007/s12253-019-00612-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Suppressor of cytokine signaling1 (SOCS1), as a member of SOCS family, has been widely studied in recent years. It has been found that SOCS1 not only participates in cell signaling, but also in ubiquitination mediated protein degradation process. Both of these two functions play an important role in the growth and proliferation of cells. Therefore, researchers speculated that SOCS1 also played an important role in tumors. This review mainly focuses on the structure, transcriptional regulation and functions of SOCS1 protein, and finally describes the possible clinical role of SOCS1 protein in tumors.

引用

页码：1295 / 1301

页数：7

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