Cardiovascular diseases in elderly survivors of diffuse large B-cell lymphoma: a Danish population-based cohort study

被引：1

作者：

Juul, Maja Bech ^{[1
,2
]}

Jelicic, Jelena ^{[1
,3
]}

Anru, Pavithra Laxsen ^{[4
,5
]}

Engberg, Henriette ^{[4
,5
]}

Hammershoj Jensen, Pernille ^{[6
]}

Kristensen, Helene Bjorg ^{[3
]}

Baech, Joachim ^{[7
]}

Clausen, Michael Roost ^{[3
,8
]}

Gang, Anne Ortved ^{[9
]}

Munksgaard, Lars ^{[6
]}

El-Galaly, Tarec Christoffer ^{[7
]}

Frederiksen, Henrik ^{[1
,2
,10
]}

Stauffer Larsen, Thomas ^{[1
,2
]}

机构：

[1] Odense Univ Hosp, Dept Hematol, Klovervaenget 6,Entrance 93, DK-5000 Odense C, Denmark

[2] Odense Univ Hosp, Acad Geriatr Canc Res, Odense, Denmark

[3] Vejle Sygehus, Dept Hematol, Vejle, Denmark

[4] Univ Southern Denmark, Res Unit Clin Epidemiol, Dept Clin Res, Odense, Denmark

[5] Odense Univ Hosp, Ctr Clin Epidemiol, Odense, Denmark

[6] Zealand Univ Hosp, Dept Hematol, Roskilde, Denmark

[7] Aalborg Univ Hosp, Dept Hematol, Aalborg, Denmark

[8] Aarhus Univ Hosp, Dept Hematol, Aarhus, Denmark

[9] Rigshosp, Dept Hematol, Copenhagen, Denmark

[10] Univ Southern Denmark, Dept Clin Res, Odense, Denmark

来源：

LEUKEMIA & LYMPHOMA | 2022年 / 63卷 / 09期

关键词：

Diffuse large B-cell lymphoma; anthracycline; cardiotoxicity; heart failure; venous thromboembolism; VENOUS THROMBOEMBOLISM; RISK-FACTORS; PATIENTS OLDER; HEART-FAILURE; DOXORUBICIN; STRATEGIES; RITUXIMAB; MODEL; CHOP;

D O I：

10.1080/10428194.2022.2064982

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Diffuse large B-cell lymphoma is an aggressive disease occurring primarily in elderly patients. Despite high curative rates with doxorubicin-containing treatment, some elderly patients receive less intensive treatments, mainly due to advanced age, comorbidities, and concerns of cardiotoxicity from doxorubicin-containing regimens. We analyzed 1009 patients aged 75 years or older and 10,090 age- and sex-matched comparisons. We aimed to evaluate long-term cardiovascular side effects in elderly patients treated with doxorubicin. Approximately, 64% of patients received doxorubicin-containing treatment. These patients had a persistently increased risk of new-onset heart failure with a hazard ratio of 1.5 and 1.7 when conditioning on survival without heart failure to 6 and 24 months, respectively. Moreover, we observed an increased risk of venous thromboembolism during the first six months following the lymphoma diagnosis. On the contrary, no difference in risk of developing ischemic heart disease or stroke following doxorubicin-containing treatment was observed.

引用

页码：2074 / 2083

页数：10

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