The Reversed Clock Drawing Test Phenomenon in Alzheimer's Disease: A Perfusion SPECT Study

被引:8
作者
Brugnolo, A. [1 ]
Morbelli, S. [2 ]
Dessi, B. [1 ]
Girtler, N. [3 ]
Mazzei, D. [1 ]
Fama, F. [1 ]
Barbieri, P. [1 ]
Cabassi, G. [1 ]
Koulibaly, P. M. [4 ]
Sambuceti, G. [2 ]
Rodriguez, G. [1 ]
Nobili, F. [1 ]
机构
[1] Univ Genoa, Dept Neurosci Ophthalmol & Genet, IT-16132 Genoa, Italy
[2] Univ Genoa, Dept Internal Med, IT-16132 Genoa, Italy
[3] Univ Genoa, Dept Law Med, IT-16132 Genoa, Italy
[4] Univ Nice Sophia Antipolis, TIRO CEA, Ctr Antoine Lacassagne, Dept Nucl Med, Nice, France
关键词
Brain single photon emission computed tomography; Reversed clock; Alzheimer's disease; Apraxia; MILD COGNITIVE IMPAIRMENT; RIGHT-HEMISPHERE SYNDROME; CEREBRAL-BLOOD-FLOW; INTERNATIONAL WORKSHOP; TEST-PERFORMANCE; SCREENING-TEST; DEMENTIA; BRAIN; HIPPOCAMPAL; DIAGNOSIS;
D O I
10.1159/000270898
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Aim: To unveil a brain single photon emission computed tomography (SPECT) pattern in Alzheimer's disease (AD) patients, showing a reversed clock drawing test (CDT) phenomenon. Patients and Methods: Among 1,005 consecutive subjects, 9 AD patients who drew a reversed CDT (AD-R) underwent SPECT, which was analysed (SPM2) versus a group of 10 AD patients performing the CDT correctly (AD+) and versus 15 controls (CTR). Brain SPECT in 11 AD patients who mistook the CDT in a common way (AD-) was compared with AD+ and CTR groups. Results: Relative hypoperfusion was found in AD-R versus CTR in right medial frontal, parahippocampal and subcallosal gyri, and in left insula and superior temporal gyrus. Hypoperfusion was found in AD-R versus AD+ in the right uncus, superior temporal and parahippocampal gyri. In the AD-versus CTR comparison, hypoperfusion was found in left hippocampus, parahippocampal gyrus and superior parietal lobule. In AD-R versus AD+ and CTR merged together, the analysis showed hypoperfusion in the right parahippocampus, medial frontal gyrus, superior temporal gyrus and uncus, in the left insula and superior temporal gyrus. Conclusion: Fronto-temporal dysfunction, especially in the right hemisphere, plays a role in the reversed CDT phenomenon in AD patients, whereas matched AD patients mistaking the CDT in a common way show left posterior temporo-parietal hypoperfusion. Copyright (C) 2010 S. Karger AG, Basel
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页码:1 / 10
页数:10
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