Can genetic-based advice help you lose weight? Findings from the Food4Me European randomized controlled trial

被引：49

作者：

Celis-Morales, Carlos ^{[1
,2
]}

Marsaux, Cyril F. M. ^{[3
]}

Livingstone, Katherine M. ^{[1
]}

Navas-Carretero, Santiago ^{[4
]}

San-Cristobal, Rodrigo ^{[4
]}

Fallaize, Rosalind ^{[5
,6
]}

Macready, Anna L. ^{[5
,6
]}

O'Donovan, Clare ^{[7
]}

Woolhead, Clara ^{[7
]}

Forster, Hannah ^{[7
]}

Kolossa, Silvia ^{[8
]}

Daniel, Hannelore ^{[8
]}

Moschonis, George ^{[9
]}

Mavrogianni, Christina ^{[9
]}

Manios, Yannis ^{[9
]}

Surwillo, Agnieszka ^{[10
]}

Traczyk, Iwona ^{[10
]}

Drevon, Christian A. ^{[11
]}

Grimaldi, Keith ^{[12
]}

Bouwman, Jildau ^{[13
]}

Gibney, Mike J. ^{[7
]}

Walsh, Marianne C. ^{[7
]}

Gibney, Eileen R. ^{[7
]}

Brennan, Lorraine ^{[7
]}

Lovegrove, Julie A. ^{[5
,6
]}

Alfredo Martinez, J. ^{[4
]}

Saris, Wim H. M.

Mathers, John C. ^{[1
]}

机构：

[1] Newcastle Univ, Inst Cellular Med, Human Nutr Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England

[2] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow Cardiovasc Res Ctr, Glasgow, Lanark, Scotland

[3] Maastricht Univ, Med Ctr, Sch Nutr & Translat Res Metab NUTRIM, Dept Human Biol, Maastricht, Netherlands

[4] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona, Spain

[5] Univ Reading, Hugh Sinclair Unit Human Nutr, Reading, Berks, England

[6] Univ Reading, Inst Cardiovasc & Metab Res, Reading, Berks, England

[7] UCD, Inst Food & Hlth, Dublin, Ireland

[8] Tech Univ Munich, Biochem Unit, Res Ctr Nutr & Food Sci ZIEL, Munich, Germany

[9] Harokopio Univ, Dept Nutr & Dietet, Athens, Greece

[10] Natl Food & Nutr Inst, Warsaw, Poland

[11] Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, Oslo, Norway

[12] Eurogenetica Ltd, Burnham on Sea, England

[13] Netherlands Org Appl Sci Res TNO, Microbiol & Syst Biol Grp, Zeist, Netherlands

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2017年 / 105卷 / 05期

基金：

欧盟第七框架计划;

关键词：

FTO; genotype; personalized nutrition; randomized controlled trial; weight; BODY-MASS INDEX; PHYSICAL-ACTIVITY; PERSONALIZED NUTRITION; FTO; INTERVENTIONS; INTERNET; OBESITY; ADULTS; WEB; TECHNOLOGY;

D O I：

10.3945/ajcn.116.145680

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: There has been limited evidence about whether genotype-tailored advice provides extra benefits in reducing obesity-related traits compared with the benefits of conventional one-size-fitsall advice. Objective: We determined whether the disclosure of information on fat-mass and obesity-associated (FTO) genotype risk had a greater effect on a reduction of obesity-related traits in risk carriers than in nonrisk carriers across different levels of personalized nutrition. Design: A total of 683 participants (women: 51%; age range: 18-73 y) from the Food4Me randomized controlled trial were included in this analysis. Participants were randomly assigned to 4 intervention arms as follows: level 0, control group; level 1, dietary group; level 2, phenotype group; and level 3, genetic group. FTO (single nucleotide polymorphism rs9939609) was genotyped at baseline in all participants, but only subjects who were randomly assigned to level 3 were informed about their genotypes. Level 3 participants were stratified into risk carriers (AA/AT) and nonrisk carriers (TT) of the FTO gene for analyses. Height, weight, and waist circumference (WC) were self-measured and reported at baseline and months 3 and 6. Results: Changes in adiposity markers were greater in participants who were informed that they carried the FTO risk allele (level 3 AT/AA carriers) than in the nonpersonalized group (level 0) but not in the other personalized groups (level 1 and 2). Mean reductions in weight and WC at month 6 were greater for FTO risk carriers than for noncarriers in the level 3 group [-2.28 kg (95% CI: -3.06, -1.48 kg) compared with -1.99 kg (-2.19, -0.19 kg), respectively (P = 0.037); and -4.34 cm (-5.63, -3.08 cm) compared with -1.99 cm (-4.04, -0.05 cm), respectively, (P = 0.048)]. Conclusions: There are greater body weight and WC reductions in risk carriers than in nonrisk carriers of the FTO gene.

引用

页码：1204 / 1213

页数：10

共 38 条

[1] A Randomized Clinical Trial Evaluating Online Interventions to Improve Fruit and Vegetable Consumption [J].

Alexander, Gwen L. ;

McClure, Jennifer B. ;

Calvi, Josephine H. ;

Divine, George W. ;

Stopponi, Melanie A. ;

Rolnick, Sharon J. ;

Heimendinger, Jerianne ;

Tolsma, Dennis D. ;

Resnicow, Kenneth ;

Campbell, Marci K. ;

Strecher, Victor J. ;

Johnson, Christine Cole .

AMERICAN JOURNAL OF PUBLIC HEALTH, 2010, 100 (02) :319-326

[2]

[Anonymous], 2009, GLOB HLTH RISK MORT

[3] Improved weight management using genetic information to personalize a calorie controlled diet [J].

Arkadianos, Ioannis ;

Valdes, Ana M. ;

Marinos, Efstathios ;

Florou, Anna ;

Gill, Rosalynn D. ;

Grimaldi, Keith A. .

NUTRITION JOURNAL, 2007, 6 (1)

[4] Impact of direct-to-consumer genomic testing at long term follow-up [J].

Bloss, Cinnamon S. ;

Wineinger, Nathan E. ;

Darst, Burcu F. ;

Schork, Nicholas J. ;

Topol, Eric J. .

JOURNAL OF MEDICAL GENETICS, 2013, 50 (06) :393-400

[5] Effect of Direct-to-Consumer Genomewide Profiling to Assess Disease Risk. [J].

Bloss, Cinnamon S. ;

Schork, Nicholas J. ;

Topol, Eric J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (06) :524-534

[6] Effect of personalized nutrition on health-related behaviour change: evidence from the Food4Me European randomized controlled trial [J].

Celis-Morales, Carlos ;

Livingstone, Katherine M. ;

Marsaux, Cyril F. M. ;

Macready, Anna L. ;

Fallaize, Rosalind ;

O'Donovan, Clare B. ;

Woolhead, Clara ;

Forster, Hannah ;

Walsh, Marianne C. ;

Navas-Carretero, Santiago ;

San-Cristobal, Rodrigo ;

Tsirigoti, Lydia ;

Lambrinou, Christina P. ;

Mavrogianni, Christina ;

Moschonis, George ;

Kolossa, Silvia ;

Hallmann, Jacqueline ;

Godlewska, Magdalena ;

Surwillo, Agnieszka ;

Traczyk, Iwona ;

Drevon, Christian A. ;

Bouwman, Jildau ;

van Ommen, Ben ;

Grimaldi, Keith ;

Parnell, Laurence D. ;

Matthews, John N. S. ;

Manios, Yannis ;

Daniel, Hannelore ;

AlfredoMartinez, J. ;

Lovegrove, Julie A. ;

Gibney, Eileen R. ;

Brennan, Lorraine ;

Saris, Wim H. M. ;

Gibney, Mike ;

Mathers, John C. .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2017, 46 (02) :578-588

[7] Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: The Food4Me study [J].

Celis-Morales, Carlos ;

Marsaux, Cyril F. M. ;

Livingstone, Katherine M. ;

Navas-Carretero, Santiago ;

San-Cristobal, Rodrigo ;

O'donovan, Clare B. ;

Forster, Hannah ;

Woolhead, Clara ;

Fallaize, Rosalind ;

Macready, Anna L. ;

Kolossa, Silvia ;

Hallmann, Jacqueline ;

Tsirigoti, Lydia ;

Lambrinou, Christina P. ;

Moschonis, George ;

Godlewska, Magdalena ;

Surwillo, Agnieszka ;

Grimaldi, Keith ;

Bouwman, Jildau ;

Manios, Yannis ;

Traczyk, Iwona ;

Drevon, Christian A. ;

Parnell, Laurence D. ;

Daniel, Hannelore ;

Gibney, Eileen R. ;

Brennan, Lorraine ;

Walsh, Marianne C. ;

Gibney, Mike ;

Lovegrove, Julie A. ;

Alfredo Martinez, J. ;

Saris, Wim H. M. ;

Mathers, John C. .

OBESITY, 2016, 24 (04) :962-969

[8] Personalising nutritional guidance for more effective behaviour change [J].

Celis-Morales, Carlos ;

Lara, Jose ;

Mathers, John C. .

PROCEEDINGS OF THE NUTRITION SOCIETY, 2015, 74 (02) :130-138

[9] How reliable is internet-based self-reported identity, socio-demographic and obesity measures in European adults? [J].

Celis-Morales, Carlos ;

Livingstone, Katherine M. ;

Woolhead, Clara ;

Forster, Hannah ;

O'Donovan, Clare B. ;

Macready, Anna L. ;

Fallaize, Rosalind ;

Marsaux, Cyril F. M. ;

Tsirigoti, Lydia ;

Efstathopoulou, Eirini ;

Moschonis, George ;

Navas-Carretero, Santiago ;

San-Cristobal, Rodrigo ;

Kolossa, Silvia ;

Klein, Ulla L. ;

Hallmann, Jacqueline ;

Godlewska, Magdalena ;

Surwillo, Agnieszka ;

Drevon, Christian A. ;

Bouwman, Jildau ;

Grimaldi, Keith ;

Parnell, Laurence D. ;

Manios, Yannis ;

Traczyk, Iwona ;

Gibney, Eileen R. ;

Brennan, Lorraine ;

Walsh, Marianne C. ;

Lovegrove, Julie A. ;

Martinez, J. Alfredo ;

Daniel, Hannelore ;

Saris, Wim H. M. ;

Gibney, Mike ;

Mathers, John C. .

GENES AND NUTRITION, 2015, 10 (05)

[10] Design and baseline characteristics of the Food4Me study: a web-based randomised controlled trial of personalised nutrition in seven European countries [J].

Celis-Morales, Carlos ;

Livingstone, Katherine M. ;

Marsaux, Cyril F. M. ;

Forster, Hannah ;

O'Donovan, Clare B. ;

Woolhead, Clara ;

Macready, Anna L. ;

Fallaize, Rosalind ;

Navas-Carretero, Santiago ;

San-Cristobal, Rodrigo ;

Kolossa, Silvia ;

Hartwig, Kai ;

Tsirigoti, Lydia ;

Lambrinou, Christina P. ;

Moschonis, George ;

Godlewska, Magdalena ;

Surwillo, Agnieszka ;

Grimaldi, Keith ;

Bouwman, Jildau ;

Daly, E. J. ;

Akujobi, Victor ;

O'Riordan, Rick ;

Hoonhout, Jettie ;

Claassen, Arjan ;

Hoeller, Ulrich ;

Gundersen, Thomas E. ;

Kaland, Siv E. ;

Matthews, John N. S. ;

Manios, Yannis ;

Traczyk, Iwona ;

Drevon, Christian A. ;

Gibney, Eileen R. ;

Brennan, Lorraine ;

Walsh, Marianne C. ;

Lovegrove, Julie A. ;

Alfredo Martinez, J. ;

Saris, Wim H. M. ;

Daniel, Hannelore ;

Gibney, Mike ;

Mathers, John C. .

GENES AND NUTRITION, 2015, 10 (01)

← 1 2 3 4 →