FMRI visualization of brain activity during a monetary incentive delay task

被引：1060

作者：

Knutson, B ^{[1
]}

Westdorp, A ^{[1
]}

Kaiser, E ^{[1
]}

Hommer, D ^{[1
]}

机构：

[1] NIAAA, Sect Brain Electrophysiol & Imaging, Div Intramural Clin & Biol Res, NIH, Bethesda, MD 20892 USA

来源：

NEUROIMAGE | 2000年 / 12卷 / 01期

关键词：

incentives; reward; punishment; monetary; caudate; putamen; thalamus; anterior cingulate; mesial prefrontal cortex; FMRI; human;

D O I：

10.1006/nimg.2000.0593

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Comparative studies have implicated striatal and mesial forebrain circuitry in the generation of autonomic, endocrine, and behavioral responses for incentives. Using blood oxygen level-dependent functional magnetic resonance imaging, we sought to visualize functional activation of these regions in 12 normal volunteers as they anticipated and responded for monetary incentives. Both individual and group analyses of time-series data revealed significant activation of striatal and mesial forebrain structures (including insula, caudate, putamen, and mesial prefrontal cortex) during trials involving both monetary rewards and punishments. In addition to these areas, during trials involving punishment, group analysis revealed activation foci in the anterior cingulate and thalamus. These results corroborate comparative studies which implicate striatal and mesial forebrain circuitry in the elaboration of incentive-driven behavior. This report also introduces a new paradigm for probing the functional integrity of this circuitry in humans.

引用

页码：20 / 27

页数：8

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