Aβ deposition is essential to AD neuropathology

被引：7

作者：

Estus, Steve ^{[1
]}

Borchelt, David ^{[2
]}

Kindy, Mark S. ^{[1
]}

Vassar, Robert ^{[3
]}

机构：

[1] Univ Kentucky, Lexington, KY USA

[2] Johns Hopkins Univ, Baltimore, MD USA

[3] Northwestern Univ, Chicago, IL 60611 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2002年 / 4卷 / 03期

关键词：

D O I：

10.3233/JAD-2002-4302

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

[No abstract available]

引用

页码：133 / 138

页数：6

共 62 条

[1] Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome [J].

Altafaj, X ;

Dierssen, M ;

Baamonde, C ;

Martí, E ;

Visa, J ;

Guimerà, J ;

Oset, M ;

González, JR ;

Flórez, J ;

Fillat, C ;

Estivill, X .

HUMAN MOLECULAR GENETICS, 2001, 10 (18) :1915-1923

[2] Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease [J].

Bard, F ;

Cannon, C ;

Barbour, R ;

Burke, RL ;

Games, D ;

Grajeda, H ;

Guido, T ;

Hu, K ;

Huang, JP ;

Johnson-Wood, K ;

Khan, K ;

Kholodenko, D ;

Lee, M ;

Lieberburg, I ;

Motter, R ;

Nguyen, M ;

Soriano, F ;

Vasquez, N ;

Weiss, K ;

Welch, B ;

Seubert, P ;

Schenk, D ;

Yednock, T .

NATURE MEDICINE, 2000, 6 (08) :916-919

[3] Evidence for genetic linkage of Alzheimer's disease to chromosome 10q [J].

Bertram, L ;

Blacker, D ;

Mullin, K ;

Keeney, D ;

Jones, J ;

Basu, S ;

Yhu, S ;

McInnis, MG ;

Go, RCP ;

Vekrellis, K ;

Selkoe, DJ ;

Saunders, AJ ;

Tanzi, RE .

SCIENCE, 2000, 290 (5500) :2302-+

[4] Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins [J].

Borchelt, DR ;

Ratovitski, T ;

vanLare, J ;

Lee, MK ;

Gonzales, V ;

Jenkins, NA ;

Copeland, NG ;

Price, DL ;

Sisodia, SS .

NEURON, 1997, 19 (04) :939-945

[5] Familial Alzheimer's disease-linked presenilin 1 variants elevate A beta 1-42/1-40 ratio in vitro and in vivo [J].

Borchelt, DR ;

Thinakaran, G ;

Eckman, CB ;

Lee, MK ;

Davenport, F ;

Ratovitsky, T ;

Prada, CM ;

Kim, G ;

Seekins, S ;

Yager, D ;

Slunt, HH ;

Wang, R ;

Seeger, M ;

Levey, AI ;

Gandy, SE ;

Copeland, NG ;

Jenkins, NA ;

Price, DL ;

Younkin, SG .

NEURON, 1996, 17 (05) :1005-1013

[6] RELEASE OF EXCESS AMYLOID BETA-PROTEIN FROM A MUTANT AMYLOID BETA-PROTEIN PRECURSOR [J].

CAI, XD ;

GOLDE, TE ;

YOUNKIN, SG .

SCIENCE, 1993, 259 (5094) :514-516

[7] Purified recombinant insulin-degrading enzyme degrades amyloid β-protein but does not promote its oligomerization [J].

Chesneau, V ;

Vekrellis, K ;

Rosner, MR ;

Selkoe, DJ .

BIOCHEMICAL JOURNAL, 2000, 351 :509-516

[8] MUTATION OF THE BETA-AMYLOID PRECURSOR PROTEIN IN FAMILIAL ALZHEIMERS-DISEASE INCREASES BETA-PROTEIN PRODUCTION [J].

CITRON, M ;

OLTERSDORF, T ;

HAASS, C ;

MCCONLOGUE, L ;

HUNG, AY ;

SEUBERT, P ;

VIGOPELFREY, C ;

LIEBERBURG, I ;

SELKOE, DJ .

NATURE, 1992, 360 (6405) :672-674

[9] THE STRUCTURE OF THE PRESENILIN-1 (S182) GENE AND IDENTIFICATION OF 6 NOVEL MUTATIONS IN EARLY-ONSET AD FAMILIES [J].

CLARK, RF ;

HUTTON, M ;

FULDNER, RA ;

FROELICH, S ;

KARRAN, E ;

TALBOT, C ;

CROOK, R ;

LENDON, C ;

PRIHAR, G ;

HE, C ;

KORENBLAT, K ;

MARTINEZ, A ;

WRAGG, M ;

BUSFIELD, F ;

BEHRENS, MI ;

MYERS, A ;

NORTON, J ;

MORRIS, J ;

MEHTA, N ;

PEARSON, C ;

LINCOLN, S ;

BAKER, M ;

DUFF, K ;

ZEHR, C ;

PEREZTUR, J ;

HOULDEN, H ;

RUIZ, A ;

OSSA, J ;

LOPERA, F ;

ARCOS, M ;

MADRIGAL, L ;

COLLINGE, J ;

HUMPHREYS, C ;

ASHWORTH, A ;

SARNER, S ;

FOX, N ;

HARVEY, R ;

KENNEDY, A ;

ROQUES, P ;

CLINE, RT ;

PHILLIPS, CA ;

VENTER, JC ;

FORSELL, L ;

AXELMAN, K ;

LILIUS, L ;

JOHNSTON, J ;

COWBURN, R ;

VIITANEN, M ;

WINBLAD, B ;

KOSIK, K .

NATURE GENETICS, 1995, 11 (02) :219-222

[10] IMPLANTS CONTAINING BETA-AMYLOID PROTEIN ARE NOT NEUROTOXIC TO YOUNG AND OLD RAT-BRAIN [J].

CLEMENS, JA ;

STEPHENSON, DT .

NEUROBIOLOGY OF AGING, 1992, 13 (05) :581-586

← 1 2 3 4 5 6 7 →