Auxiliary subunits: essential components of the voltage-gated calcium channel complex

被引：386
作者：
Arikkath, J
Campbell, KP
机构：
[1] Univ Iowa, Howard Hughes Med Inst, Dept Phys & Biophys, Coll Med, Iowa City, IA 52242 USA
[2] Univ Iowa, Howard Hughes Med Inst, Dept Neurol, Coll Med, Iowa City, IA 52242 USA
来源：
CURRENT OPINION IN NEUROBIOLOGY | 2003年 / 13卷 / 03期
关键词：
D O I：
10.1016/S0959-4388(03)00066-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Voltage-gated calcium channels are important mediators of several physiological processes, including neuronal excitability and muscle contraction. At the molecular level, the channels are composed of four subunits - the pore forming alpha(1) subunit and the auxiliary alpha(2)delta, beta and gamma subunits. The auxiliary subunits modulate the trafficking and the biophysical properties of the alpha(1) subunit. In the past several years there has been an acceleration of our understanding of the auxiliary subunits, primarily because of their molecular characterization and the availability of spontaneous and targeted mouse mutants. These studies have revealed the crucial role of the subunits in the functional effects that are mediated by voltage-gated calcium channels.
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收藏
页码：298 / 307
页数：10
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