Cisplatin and paclitaxel for non-small-cell lung cancer: The European experience

被引:0
作者
Postmus, PE [1 ]
机构
[1] Vrije Univ Amsterdam, Univ Hosp, Dept Pulmonol, Amsterdam, Netherlands
来源
ONCOLOGY-NEW YORK | 1999年 / 13卷 / 09期
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Many physicians have questioned whether the additional survival benefit gained from the use of combination chemotherapy in non-small-cell lung cancel has been offset by chemotherapy-induced toxicity, particularly with cisplatin (Platinol). However, the impressive efficacy of paclitaxel (Taxol) (1-year survival > 40%) made its combination with cisplatin logical, When compared to older standard regimens (eg, cisplatin and teniposide [Vumon]) paclitaxel and cisplatin resulted in significantly higher response rates but comparable survival rates at 1 and 2 years. The paclitaxel and cisplatin regimen was better tolerated. Further studies are required to evaluate the combination of paclitaxel with newer agents to reduce toxicity and develop simple, outpatient regimens.
引用
收藏
页码:26 / 29
页数:4
相关论文
共 13 条
[1]  
ALBERTI W, 1995, BRIT MED J, V311, P899
[2]  
BELLI L, 1995, P AN M AM SOC CLIN, V14, P350
[3]   PHASE-II STUDY OF TAXOL, MERBARONE, AND PIROXANTRONE IN STAGE-IV NON-SMALL-CELL LUNG-CANCER - THE EASTERN COOPERATIVE ONCOLOGY GROUP RESULTS [J].
CHANG, AY ;
KIM, K ;
GLICK, J ;
ANDERSON, T ;
KARP, D ;
JOHNSON, D .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (05) :388-394
[4]  
Giaccone G, 1996, BRIT J HOSP MED, V55, P634
[5]  
GIACCONE G, UNPUB J CLIN ONCOL
[6]  
KLASTERSKY J, 1995, LUNG CANCER, V12, P117
[7]   PHASE-II STUDY OF TAXOL IN PATIENTS WITH UNTREATED ADVANCED NON-SMALL-CELL LUNG-CANCER [J].
MURPHY, WK ;
FOSSELLA, FV ;
WINN, RJ ;
SHIN, DM ;
HYNES, HE ;
GROSS, HM ;
DAVILLA, E ;
LEIMERT, J ;
DHINGRA, H ;
RABER, MN ;
KRAKOFF, IH ;
HONG, WK .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (05) :384-388
[8]   Paclitaxel cisplatin in advanced non-small-cell lung cancer (NSCLC) [J].
Pirker, R ;
Krajnik, G ;
Zochbauer, S ;
Malayeri, R ;
Kneussl, M ;
Huber, H .
ANNALS OF ONCOLOGY, 1995, 6 (08) :833-835
[9]  
Postmus PE, 1996, SEMIN ONCOL, V23, P10
[10]   SEQUENCES OF TAXOL AND CISPLATIN - A PHASE-I AND PHARMACOLOGICAL STUDY [J].
ROWINSKY, EK ;
GILBERT, MR ;
MCGUIRE, WP ;
NOE, DA ;
GROCHOW, LB ;
FORASTIERE, AA ;
ETTINGER, DS ;
LUBEJKO, BG ;
CLARK, B ;
SARTORIUS, SE ;
CORNBLATH, DR ;
HENDRICKS, CB ;
DONEHOWER, RC .
JOURNAL OF CLINICAL ONCOLOGY, 1991, 9 (09) :1692-1703