Molar scale electrosynthesis of ethyl-2,2-difluoro-2-trimethylsilylacetate, a difluoromethylene building block

被引：25

作者：

Clavel, P

Biran, C

Bordeau, M

Roques, N

Trévin, S

机构：

[1] Univ Bordeaux 1, Chim Organ & Organomet Lab, F-33405 Talence, France

[2] Rhodia Organ Fine, F-69192 St Fons, France

[3] Elect France, Dept Applicat Elect Ind, Direct Etud & Rech, F-77818 Moret Sur Loing, France

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 45期

关键词：

electrosynthesis; ethyl-2,2-difluoro-2-trimethylsilylacetate CF2COOEt-building block;

D O I：

10.1016/S0040-4039(00)01509-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ethyl-2,2-difluoro-2-trimethylsilylacetate has been prepared by electrolysis of ethyl-2-chloro-2,2-difluoroacetate in one step, at a molar scale, in the presence of a large excess of chlorotrimethylsilane. The transfer of the ethyl-2,2-difluoroacetate moiety to various electrophiles has been achieved. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：8763 / 8767

页数：5

共 16 条

[1]

[Anonymous], 1991, Fluorine in Bioorganic Chemistry

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