Synaptotagmin in Ca2+-Dependent exocytosis:: Dynamic action in a flash

被引:28
作者
Tokuoka, H
Goda, Y
机构
[1] UCL, MRC, Cell Biol Unit, London WC1E 6BT, England
[2] UCL, Mol Cell Biol Lab, London WC1E 6BT, England
关键词
D O I
10.1016/S0896-6273(03)00290-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Synaptotagmins have been the popular candidates for the Ca2+ sensor that couples local rise in Ca2+ to neurotransmitter release. Studies in worm, fly, and mouse corroborate the likely role for synaptotagmin I, the best-studied synaptotagmin prototype, as a Ca2+ trigger for synaptic vesicle exocytosis. Recent investigations have focused on structural domains of synaptotagmin that are critical for its function. Here we provide a brief overview of synaptotagmin I and discuss recent studies within the framework of neurotransmitter release mechanisms for fast synaptic transmission.
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收藏
页码:521 / 524
页数:4
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