Synaptotagmin in Ca2+-Dependent exocytosis:: Dynamic action in a flash

被引：28
作者：
Tokuoka, H
Goda, Y
机构：
[1] UCL, MRC, Cell Biol Unit, London WC1E 6BT, England
[2] UCL, Mol Cell Biol Lab, London WC1E 6BT, England
来源：
NEURON | 2003年 / 38卷 / 04期
关键词：
D O I：
10.1016/S0896-6273(03)00290-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Synaptotagmins have been the popular candidates for the Ca2+ sensor that couples local rise in Ca2+ to neurotransmitter release. Studies in worm, fly, and mouse corroborate the likely role for synaptotagmin I, the best-studied synaptotagmin prototype, as a Ca2+ trigger for synaptic vesicle exocytosis. Recent investigations have focused on structural domains of synaptotagmin that are critical for its function. Here we provide a brief overview of synaptotagmin I and discuss recent studies within the framework of neurotransmitter release mechanisms for fast synaptic transmission.
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页码：521 / 524
页数：4
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