Bulbar conjunctival microvascular responses in dry eye

被引:28
作者
Chen, Wan [1 ,2 ]
Batawi, Hatim Ismail M. [2 ,3 ]
Alava, Jimmy R. [3 ]
Galor, Anat [2 ,3 ]
Yuan, Jin [1 ,2 ]
Sarantopoulos, Constantine D. [3 ,4 ]
McClellan, Allison L. [3 ]
Feuer, William J. [2 ]
Levitt, Roy C. [3 ,4 ,5 ]
Wang, Jianhua [2 ]
机构
[1] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, Guangzhou, Guangdong, Peoples R China
[2] Univ Miami, Miller Sch Med, Bascom Palmer Eye Inst, Miami, FL 33136 USA
[3] Miami Vet Adm Med Ctr, Miami, FL USA
[4] Univ Miami, Miller Sch Med, Dept Anesthesiol Perioperat Med & Pain Management, Miami, FL 33136 USA
[5] Univ Miami, Miller Sch Med, John P Hussman Inst Human Genom, John T Macdonald Fdn,Dept Human Genet, Miami, FL 33136 USA
关键词
Blood flow velocity; Corneal sensitivity; Fractal dimension; Neuropathic ocular pain; Functional slit lamp biomicroscopy; DECREASED CORNEAL SENSITIVITY; SLIT LAMP BIOMICROSCOPY; CEREBRAL BLOOD-FLOW; PAIN INTENSITY; SYMPATHETIC INNERVATION; ELECTRICAL-STIMULATION; INTRAVITAL MICROSCOPY; CLUSTER HEADACHE; NEUROPATHIC PAIN; NERVE-FIBERS;
D O I
10.1016/j.jtos.2016.12.002
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: Conjunctival microvascular responses may be a surrogate metric of efferent neural pathway function innervating the ocular surface as changes in blood flow occur within seconds after a stimulus. As somatosensory dysfunction may partially underlie dry eye (DE), in this study we evaluate whether bulbar conjunctival microvascular alterations correlate with various aspects of DE. Methods: Fifty-six DE patients were prospectively recruited from a Veterans Affairs ophthalmology clinic over an 11-month period. DE symptoms and ocular pain were assessed along with DE signs. A novel functional slit lamp biomicroscope (FSLB) was used to image the temporal bulbar conjunctiva from the right eye before and after central corneal stimulation with an air puff. Blood flow velocities were measured and noninvasive microvascular perfusion maps (nMPMs) were created. Results: The bulbar blood flow velocity was 0.50 +/- 0.15 mm/s at baseline and increased to 0.55 +/- 0.17 mm/s after stimulation (P < 0.001); the average change in velocity was 0.05 +/- 0.09. nMPMs values and venule diameter, on the other hand, did not significantly increase after stimulation (1.64 +/- 0.004 at baseline, 1.65 +/- 0.04 after stimulation, P = 0.22 and 22.13 +/- 1.84 mm at baseline, 22.21 +/- 2.04 mm after stimulation, P = 0.73, respectively). Baseline blood flow velocity positively associated with Schirmer scores (r = 0.40, P = 0.002). Those with higher self-rated wind hyperalgesia demonstrated less change in blood flow velocity (r = -0.268, P = 0.046) after air stimulation on the central cornea. Conclusion: Conjunctival blood flow velocity, but not vessel diameter or complexity, increases after wind stimuli. Baseline flow positively correlated with Schirmer scores while change in flow negatively correlated with self-reported wind hyperalgesia. Published by Elsevier Inc.
引用
收藏
页码:193 / 201
页数:9
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