Angiogenic factors: potential to change clinical practice in pre-eclampsia?

被引:59
作者
Cerdeira, A. S. [1 ]
Agrawal, S. [1 ,3 ]
Staff, A. C. [2 ]
Redman, C. W. [1 ]
Vatish, M. [1 ]
机构
[1] Univ Oxford, Nuffield Dept Obstet & Gynaecol, Oxford, England
[2] Univ Oslo, Oslo Univ Hosp, Div Obstet & Gynaecol, Oslo, Norway
[3] Univ Toronto, St Michaels Hosp, Toronto, ON, Canada
关键词
Angiogenic factors; fms-like tyrosine kinase 1; National Institute for Clinical Excellence; placental growth factor; pre-eclampsia; pregnancy; PLACENTAL GROWTH-FACTOR; TYROSINE KINASE 1; HYPERTENSIVE DISORDERS; SFLT-1/PLGF RATIO; SOLUBLE ENDOGLIN; HIGH-RISK; SUPERIMPOSED PREECLAMPSIA; SUSPECTED PREECLAMPSIA; ADVERSE OUTCOMES; TWIN PREGNANCIES;
D O I
10.1111/1471-0528.15042
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Pre-eclampsia is a complex disease with significant maternal and fetal morbidity and mortality. Its syndromic nature makes diagnosis and management difficult. The field is rapidly evolving with the definition of pre-eclampsia being challenged by some organisations, with proteinuria no longer being essential in the presence of other features. In the last decade, angiogenic factors, in particular soluble fms-like tyrosine kinase 1 (sFlt-1), have emerged as important molecules in the pathogenesis of pre-eclampsia. Here we review the most recent evidence regarding the potential of these factors as biomarkers and therapeutic targets for pre-eclampsia. Tweetable abstractA review of angiogenic factors, sFlt-1 and PlGF, in the diagnosis, prediction and management of pre-eclampsia. Tweetable abstract A review of angiogenic factors, sFlt-1 and PlGF, in the diagnosis, prediction and management of pre-eclampsia.
引用
收藏
页码:1389 / 1395
页数:7
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