miR-184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7

被引：18
作者：
Chen, Daiyun [1 ]
Li, Junfu [1 ]
Li, Shunrong [2 ]
Han, Ping [3 ]
Li, Ning [4 ]
Wang, Yi [3 ]
Du, Shouqin [4 ]
机构：
[1] Taishan Med Univ, Affiliated Hosp, Dept Stomatol, 706 Taishan St, Tai An 271000, Shandong, Peoples R China
[2] Peoples Hosp Zhangqiu, Dept Crit Care Med, Zhangqiu 250200, Shandong, Peoples R China
[3] Peoples Hosp Zhangqiu, Dept Resp Med, Zhangqiu 250200, Shandong, Peoples R China
[4] Peoples Hosp Zhangqiu, Dept Pathol, Zhangqiu 250200, Shandong, Peoples R China
来源：
ONCOLOGY LETTERS | 2018年 / 16卷 / 02期
关键词：
luciferase reporter assay; miR-184; sex-determining region Y-box 7; tongue squamous cell carcinoma; TUMOR-SUPPRESSOR; BREAST-CANCER; EXPRESSION; MICRORNA; MIRNAS; SRY;
D O I：
10.3892/ol.2018.8906
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim of this study was to investigate whether the miR-184 could regulate the proliferation of the tongue squamous cell carcinoma (TSCC) through sex-determining region Y-box 7 (SOX7) gene. miR-184 expression was upregulated in TSCC cell lines and tissues. MTT assay revealed that overexpression of miR-184 significantly promoted the proliferation of the TSCC cells in vitro. SOX7 was the direct target of miR-184 and luciferase reporter assay confirmed that miR-184 downregulated the expression of SOX7. MTT assay verified that knockdown of SOX7 remarkably promoted the proliferation of TSCC cells in vitro. miR-184 promoted the proliferation of TSCC by targeting SOX7. Taken together, our results provided a new potential therapeutic target for TSCC treatment.
引用
收藏
页码：2221 / 2228
页数：8
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