Microwave-assisted synthesis of some bi- and tricyclic pyrimidine derivatives

被引：26

作者：

Foroughifar, N ^{[1
]}

Mobinikhaledi, A ^{[1
]}

Jirandehi, HF ^{[1
]}

Memar, S ^{[1
]}

机构：

[1] Arak Univ, Dept Chem, Arak, Iran

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2003年 / 178卷 / 06期

关键词：

bromomalononitrile; microwave; neutral alumina; pyrimidine;

D O I：

10.1080/10426500307886

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Pyrimidine derivatives 4a-4c was prepared by a Biginelli cyclocondensation of beta-ketoesters, aryl aldehydes, and thiourea derivatives under microwave irradiation. A simple and fast synthesis of bicyclic pyrimidine derivatives 6a-6c was performed by microwave-assisted reaction of 4a-4c with bromomalononitrile (5). Reaction of bicyclic pyrimidines 6a-6c with HCO2H and HONH3Cl under microwave irradiation gave tricyclic pyrimidines 7a-7c and 8a-8c respectively.

引用

页码：1269 / 1276

页数：8

共 18 条

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