Prevalence of Latent Rheumatic Heart Disease Among HIV-Infected Children in Kampala, Uganda

被引：17
作者：
Gleason, Brigette [1 ,2 ]
Mirembe, Grace [3 ]
Namuyonga, Judith [4 ,5 ]
Okello, Emmy [4 ,5 ]
Lwabi, Peter [4 ,5 ]
Lubega, Irene [4 ,5 ]
Lubega, Sulaiman [4 ,5 ]
Musiime, Victor [3 ,4 ]
Kityo, Cissy [3 ]
Salata, Robert A. [1 ,2 ]
Longenecker, Chris T. [1 ,2 ]
机构：
[1] Case Western Reserve Univ, Sch Med, Cleveland, OH 44106 USA
[2] Univ Hosp Case Med Ctr, Cleveland, OH USA
[3] Joint Clin Res Ctr, Kampala, Uganda
[4] Makerere Univ, Sch Med, Kampala, Uganda
[5] Uganda Heart Inst, Kampala, Uganda
来源：
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2016年 / 71卷 / 02期
基金：
美国国家卫生研究院;
关键词：
rheumatic heart disease; HIV; AIDS; echocardiogram; cotrimoxazole; IMMUNODEFICIENCY-VIRUS-INFECTION; ANTIRETROVIRAL THERAPY; ECHOCARDIOGRAPHY;
D O I：
10.1097/QAI.0000000000000827
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Rheumatic heart disease (RHD) remains highly prevalent in resource-constrained settings around the world, including countries with high rates of HIV/AIDS. Although both are immune-mediated diseases, it is unknown whether HIV modifies the risk or progression of RHD. We performed screening echocardiography to determine the prevalence of latent RHD in 488 HIV-infected children aged 5-18 in Kampala, Uganda. The overall prevalence of borderline/definite RHD was 0.82% (95% confidence interval: 0.26% to 2.23%), which is lower than the published prevalence rates of 1.5%-4% among Ugandan children. There may be protective factors that decrease the risk of RHD in HIV-infected children.
引用
收藏
页码：196 / 199
页数：4
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