Prevalence of Latent Rheumatic Heart Disease Among HIV-Infected Children in Kampala, Uganda

被引：17

作者：

Gleason, Brigette ^{[1
,2
]}

Mirembe, Grace ^{[3
]}

Namuyonga, Judith ^{[4
,5
]}

Okello, Emmy ^{[4
,5
]}

Lwabi, Peter ^{[4
,5
]}

Lubega, Irene ^{[4
,5
]}

Lubega, Sulaiman ^{[4
,5
]}

Musiime, Victor ^{[3
,4
]}

Kityo, Cissy ^{[3
]}

Salata, Robert A. ^{[1
,2
]}

Longenecker, Chris T. ^{[1
,2
]}

机构：

[1] Case Western Reserve Univ, Sch Med, Cleveland, OH 44106 USA

[2] Univ Hosp Case Med Ctr, Cleveland, OH USA

[3] Joint Clin Res Ctr, Kampala, Uganda

[4] Makerere Univ, Sch Med, Kampala, Uganda

[5] Uganda Heart Inst, Kampala, Uganda

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2016年 / 71卷 / 02期

基金：

美国国家卫生研究院;

关键词：

rheumatic heart disease; HIV; AIDS; echocardiogram; cotrimoxazole; IMMUNODEFICIENCY-VIRUS-INFECTION; ANTIRETROVIRAL THERAPY; ECHOCARDIOGRAPHY;

D O I：

10.1097/QAI.0000000000000827

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rheumatic heart disease (RHD) remains highly prevalent in resource-constrained settings around the world, including countries with high rates of HIV/AIDS. Although both are immune-mediated diseases, it is unknown whether HIV modifies the risk or progression of RHD. We performed screening echocardiography to determine the prevalence of latent RHD in 488 HIV-infected children aged 5-18 in Kampala, Uganda. The overall prevalence of borderline/definite RHD was 0.82% (95% confidence interval: 0.26% to 2.23%), which is lower than the published prevalence rates of 1.5%-4% among Ugandan children. There may be protective factors that decrease the risk of RHD in HIV-infected children.

引用

页码：196 / 199

页数：4

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