DEVELOPMENT OF A QUANTITATIVE DETERMINATION METHOD FOR A BENZIMIDAZOLE DERIVATIVE WITH LABORATORY CODE RU-31 AND ANTIMIGRAINE ACTIVITY IN BIOLOGICAL SAMPLES

被引：0

作者：

Smirnova, L. A. ^{[1
]}

Ryabukha, A. F. ^{[1
]}

Kuznetsov, K. A. ^{[1
]}

Velikopolskaya, M. V. ^{[1
]}

Spasov, A. A. ^{[1
]}

Yakovlev, D. S. ^{[1
]}

机构：

[1] Volgograd State Med Univ, 1 Pavshikh Bortsov Sq, Volgograd 400131, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2021年 / 55卷 / 03期

关键词：

HPLC; quantitative determination; 5-HT2A-antagonists; 1-(2-diethylaminoethy)-2-(4-methoxyphenyl)imidazo[1,2-alpha]benzimidazole;

D O I：

10.1007/s11094-021-02418-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A quantitative determination method for drug substance RU-31, a derivative of a methoxyphenylimidazo - [1,2-alpha]benzimidazole possessing antimigraine activity, in biological samples was developed. This method has selectivity and high sensitivity sufficient to allow its use for pharmacokinetic studies of RU-31. The sensitivity of the method (detection limit) for RU-31 is 100 ng/mL; limit of quantitation, 500 ng/mL. The average measurement error is <= 15%.

引用

页码：312 / 314

页数：3