Biological Desorption Electrospray Ionization Mass Spectrometry (DESI MS) - unequivocal role of crucial ionization factors, solvent system and substrates

被引:14
|
作者
Manikandan, Muthu [1 ]
Kazibwe, Zakayo [1 ]
Hasan, Nazim [2 ]
Deenadayalan, Anbarasu [3 ]
Gopal, Judy [1 ]
Pradeep, Thalappil [4 ,5 ]
Chun, Sechul [1 ]
机构
[1] Konkuk Univ, Dept Bioresource & Food Sci, Seoul 143701, South Korea
[2] Jazan Univ, Dept Chem, Fac Med, Jazan 2097, Saudi Arabia
[3] Natl Inst Res TB ICMR, Dept Immunol, Madras 600031, Tamil Nadu, India
[4] Indian Inst Technol, Dept Chem, DST Unit Nanosci DST UNS, Madras 600036, Tamil Nadu, India
[5] Indian Inst Technol, Dept Chem, TUE, Madras 600036, Tamil Nadu, India
关键词
DESI MS; Solvent system; Substrates; Biological samples; Sample spotting; Analyte ionization; Molecular imprinting; THIN-LAYER-CHROMATOGRAPHY; AMBIENT CONDITIONS; PLANT METABOLITES; SPRAY IONIZATION; TISSUE-SECTIONS; LIPID PROFILES; DRUGS; PERFORMANCE; QUANTIFICATION; IDENTIFICATION;
D O I
10.1016/j.trac.2016.02.013
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
DESI MS, has been successfully employed for the analysis of molecules from a wide variety of surfaces without prior sample treatment. The efficiency of DESI MS relies on various parameters. However, those that critically affect the ionization of biological samples include: the solvent system and the sample or sample spotting surfaces. These parameters gain unequivocal dominance specially whilst dealing with sensitive and intricate biological samples. This review is meant to capture the attention of the DESI-MS researchers towards the crucial role of the solvent and sample spotting surfaces for successful biological DESI-MS. This review highlights these parameters as the backbone of the breakthroughs achieved in the analysis of biological materials of plant, bacterial, animal and human origins. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码:109 / 119
页数:11
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