Vitamin C - New Option in Sepsis Therapy?

被引：0

作者：

Muller, Stefan ^{[1
]}

Wiesmann, Thomas ^{[1
]}

Wulf, Hinnerk ^{[1
]}

Arndt, Christian ^{[1
]}

机构：

[1] Univ Klinikum Giessen & Marburg, Klin Anasthesie & Intens Therapie, Standort Marburg, Baldinger Str, D-35033 Marburg, Germany

来源：

ANASTHESIOLOGIE INTENSIVMEDIZIN NOTFALLMEDIZIN SCHMERZTHERAPIE | 2021年 / 56卷 / 05期

关键词：

CRITICALLY-ILL PATIENTS; SEPTIC SHOCK; ASCORBIC-ACID; THIAMINE; HYDROCORTISONE; CORTICOSTEROIDS; STRESS; INJURY; BLOOD;

D O I：

10.1055/a-1109-4363

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Vitamin C deficiency often occurs in critical illness and especially in patients with sepsis. Low plasma levels correlate with organ dysfunction and outcome parameters. Vitamin C offers pleiotropic effects possibly attenuating pathophysiology in sepsis. This includes antioxidative effects like scavenging reactive oxygen species or restoring other antioxidants. Vitamin C is a cofactor for norepinephrine biosynthesis and it protects endothelial function. In addition, it modulates immune response. A combined therapy with vitamin C, hydrocortisone and thiamine could be beneficial because of synergistic effects. Some clinical studies have shown reduced mortality due to vitamin C alone or in combination with hydrocortisone and thiamine, others do not. Adverse events are rare. So data supporting a therapy with vitamin C is still unclear. Further randomised controlled trials are necessary. © 2021 American Institute of Physics Inc.. All rights reserved.

引用

页码：374 / 382

页数：9

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