Systemic lymphoma arising from hydroa vacciniforme-like lymphoma: report of two cases with review of literature

被引：0

作者：

Yang, Yu-Qiong ^{[1
]}

Fan, Lei ^{[1
]}

Wang, Li ^{[1
]}

Xu, Ji ^{[1
]}

Zhang, Run ^{[1
]}

Ge, Zheng ^{[1
]}

Li, Jian-Yong ^{[1
]}

Xu, Wei ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Jiangsu Prov Hosp, Dept Hematol, Nanjing 210029, Jiangsu, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2014年 / 7卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Hydroa vacciniforme; lymphoma; Epstein-Barr virus infections; T-CELL LYMPHOMA; NONIMMUNOCOMPROMISED HOSTS; DISEASE;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hydroa vacciniforme-like lymphoma (HVLL) is an extremely rare lymphoma described in children that occurs mainly in Asia and Latin American countries. It is an Epstein-Barr virus (EBV)-positive lymphoproliferative disease (LPD) characterized by a monoclonal proliferation of T or NK cells. In this study, we report the clinical and pathological features of two Chinese patients with HVLL showed T-cell phenotype expressing CD4. The two patients generally presented with similar clinical histories of waxing and waning ulcerative blistering lesions for ten years or more until progression to systemic lymphoma. One patient died two months after progression and another is alive with disease. In the two cases, persistence infection of EBV may be attributed to the disease progression, and systemic lymphoma arising from HVLL behaves in an aggressive fashion and is predisposing to chemotherapeutic agent resistance.

引用

页码：6403 / 6408

页数：6