Gemtuzumab Ozogamicin Followed by Unrelated Cord Blood Transplantation With Reduced-intensity Conditioning for a Child With Refractory Acute Promyelocytic Leukemia

被引：2

作者：

Yamada, Yuji ^{[1
]}

Osumi, Tomoo ^{[1
]}

Kato, Motohiro ^{[1
]}

Shioda, Yoko ^{[1
]}

Kiyotani, Chikako ^{[1
]}

Terashima, Keita ^{[1
]}

Hayakawa, Akira ^{[2
,3
]}

Iijima-Yamashita, Yuka ^{[4
]}

Horibe, Keizo ^{[4
]}

Matsumoto, Kimikazu ^{[1
]}

Tomizawa, Daisuke ^{[1
]}

机构：

[1] Natl Ctr Child Hlth & Dev, Childrens Canc Ctr, Tokyo, Japan

[2] Kobe Univ, Dept Pediat, Kobe, Hyogo, Japan

[3] Yodogawa Christians Hosp, Dept Palliat Med, Osaka, Japan

[4] Natl Hosp Org, Clin Res Ctr, Nagoya Med Ctr, Nagoya, Aichi, Japan

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2022年 / 44卷 / 04期

关键词：

acute promyelocytic leukemia; relapsed; refractory; arsenic trioxide; all-trans retinoic acid; gemtuzumab ozogamicin; ACUTE MYELOID-LEUKEMIA; EVENT-FREE SURVIVAL; ARSENIC TRIOXIDE; ADOLESCENTS; EFFICACY; MYLOTARG; RELAPSE; 1ST; APL;

D O I：

10.1097/MPH.0000000000002404

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There is no established treatment for patients with acute promyelocytic leukemia (APL) refractory to targeted therapies with all-trans retinoic acid (ATRA) and/or arsenic trioxide (ATO). We report here a case of an 8-month-old girl with APL who failed standard ATRA-combined chemotherapy. Although molecular remission was achieved after introducing ATRA/ATO combination therapy, molecular relapse occurred during the ATO consolidation courses. Subsequent molecular remission was rapidly achieved after administering 2 doses of gemtuzumab ozogamicin. She was successfully treated with unrelated cord blood transplantation using reduced-intensity conditioning. Gemtuzumab ozogamicin might be a preferable choice for patients with APL refractory to standard therapy.

引用

页码：178 / 180

页数：3

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