Pd(0)-Catalyzed intramolecular arylative dearomatization of β-naphthols

被引：42

作者：

Xu, Ren-Qi ^{[1
]}

Yang, Ping ^{[1
]}

You, Shu-Li ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Univ Chinese Acad Sci, 345 Lingling Lu, Shanghai 200032, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 54期

关键词：

CATALYTIC ASYMMETRIC DEAROMATIZATION; HYDROXYLATIVE PHENOL DEAROMATIZATION; ENANTIOSELECTIVE DEAROMATIZATION; OXIDATIVE DEAROMATIZATION; CONSTRUCTION; EFFICIENT; INDOLES; GOLD; ACCESS; SKELETON;

D O I：

10.1039/c7cc04022a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient Pd(0)-catalyzed intramolecular arylative dearomatization of beta-naphthols is described. Using Q-Phos as a ligand, the arylative dearomatization reaction proceeded smoothly affording excellent yields and chemoselectivity even when the catalyst loading was reduced to 0.1 mol%. This method offers an efficient access to a series of structurally diverse spirocarbocycles. Preliminary investigation indicates that an enantioselective reaction is feasible in the presence of a chiral phosphoramidite ligand.

引用

页码：7553 / 7556

页数：4

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