MiPNO, a new chiral cyclic nitrone for enantioselective amino acid synthesis the cycloaddition approach

被引：23

作者：

Thiverny, Maryse ^{[1
]}

Philouze, Christian ^{[1
]}

Chavant, Pierre Yves ^{[1
]}

Blandin, Veronique ^{[1
]}

机构：

[1] Univ Grenoble 1, CNRS, ICMG FR 2607, Dept Chim Mol,UMR 5250, F-38041 Grenoble, France

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 04期

关键词：

1,3-DIPOLAR CYCLOADDITION; ALPHA-ALKOXYCARBONYLNITRONES; BUILDING-BLOCKS; N-HYDROXY; ACCESS; REARRANGEMENT; PRECURSORS; PRINCIPLE; PEPTIDES; REAGENTS;

D O I：

10.1039/b918612c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The resolution of chiral nitrones via derivatization of hydroxylamines was applied to MiPNO, a new, stable, easily prepared chiral cyclic nitrone. The application of MiPNO in totally regio- and diastereo-selective 1,3-dipolar cycloaddition reactions provides an expeditious enantioselective access to unusual gamma-hydroxy alpha-amino acids.

引用

页码：864 / 872

页数：9

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