Left Main Chronic Total Occlusion Percutaneous Coronary Intervention: A Case Series

Background. Left main coronary artery (LMCA) chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has received limited study. Methods. We reviewed 4436 CTO-PCIs performed in 4340 patients between 2012 and 2018 at 25 sites. LMCA-CTO-PCI was performed in 20 cases (0.45%). We examined the clinical and angiographic characteristics and procedural outcomes of these cases. Results. Mean patient age was 68 +/- 11 years and 65% were men. Most patients (85%) had undergone prior coronary artery bypass graft surgery and had a protected left main. Mean J-CTO score was 2.7 +/- 1.3, mean PROGRESS-CTO score was 1.3 +/- 1.1, and mean PROGRESS-CTO Complications score was 3.8 +/- 1.9. Antegrade-wire escalation was the most common successful crossing strategy (50%), followed by retrograde crossing [30%) and antegrade dissection/re-entry (10%). Technical and procedural success rates were both 85%. One patient with failed LMCA-CTO-PCI had periprocedural myocardial infarction. Median procedure time was 178 minutes (interquartile range (IQR), 123-250 minutes), median contrast volume was 190 mL (IQR, 133-339 mL), and patient air kerma radiation dose was 2.6 Gray (IQR, 1.3-3.9 Gray). Conclusions. LMCA-CTO-PCI is infrequent. is performed mostly in patients with prior coronary artery bypass graft surgery, and is associated with good procedural outcomes.